A kinetic study of DNA-based catalytic enantioselective Friedel-Crafts alkylation and Michael addition reactions showed that DNA affects the rate of these reactions significantly. Whereas in the presence of DNA, a large acceleration was found for the Friedel-Crafts alkylation and a modest acceleration in the Michael addition of dimethyl malonate, a deceleration was observed when using nitrometh...

The insulin-responsive aminopeptidase (IRAP) was recently identified as an S-acylated protein in adipocytes and other tissues. However, there is currently no information on the extent of S-acylation of this protein, the residues that are modified, or the effects of S-acylation on IRAP localisation. In this study, we employ a semi-quantitative acyl-RAC technique to show that approximately 60% of...

The functional significance and regulation of reversible S-acylation on diverse proteins remain unclear because of limited methods for efficient quantitative analysis of palmitate turnover. Here, we describe a tandem labeling and detection method to simultaneously monitor dynamic S-palmitoylation and protein turnover. By combining S-acylation and cotranslational fatty acid chemical reporters wi...

The BF3.OEt2-catalyzed Friedel-Crafts propargylation of aromatic compounds with O-propargyl trichloroacetimidates is highly efficient and affords 1,3-diarylpropyne derivatives in good yields.

Over the last 8 years, our laboratory has developed the concept of iminium catalysis, a mode of LUMO-lowering activation that has enabled the invention of a large number of enantioselective organocatalytic transformations including Diels-Alder cycloadditions, Friedel-Crafts alkylations, Mukaiyama-Michael additions, hydrogenations, and heteroconjugate additions.1 Central to the utility of this t...

P.sub.2][O.sub.5]/[H.sub.3]P[O.sub.4] (PPA) was found to be an efficient new reagent for probing the mechanism of acylation reactions and Fries rearrangement of acyloxy benzene derivatives and also the direct acylation reactions of phenol derivatives with Carboxylic acids. The reactions proceeded smoothly in the presence of PPA and are highly selective for the preparation of the ortho isomers o...