PLoS Biology | http://biology.plosjournals.org For half a century, natural products from microorganisms have been the main source of medicines for treating infectious disease. The most important chemical class of these antibiotics, apart from the penicillins, is the polyketides. They are made by the stepwise building of long carbon chains, two atoms at a time, by multifunctional enzymes that de...

Patterns of resting potential in non-excitable cells of living tissue are now known to be instructive signals for pattern formation during embryogenesis, regeneration and cancer suppression. The development of molecular-level techniques for tracking ion flows and functionally manipulating the activity of ion channels and pumps has begun to reveal the mechanisms by which voltage gradients regula...

The probable reasons for evolution of weld porosity and solidification cracking and the structure- property relationship in aluminium welds were investigated. Aluminium plates (1xxx series) were welded by Tungsten Inert Gas (TIG) welding process, 5356 filler metal was used and heat input was controlled by varying welding current (145A, 175A and 195A). The welded samples were examined under opti...

This work was supported, in part, by a grant from the Northrop Grumman Corporation, National Science Foundation Grants CPS-1329979, Science and Technology Center CCF-0939370, and EAGER-1548114. [1] Everspaugh, A., Chatterjee, R. , Scott, S., Juels, A., and Ristenpart, T. 2015. The pythia PRF service. In Proceedings of the 24th USENIX Conference on Security Symposium (SEC’15). USENIX Association...

A protein called P36 holds the key to how different species of malaria parasite invade liver cells.

Title of dissertation: FLEX CRACKING AND TEMPERATUREHUMIDITY-BIAS EFFECTS ON RELIABILITY OF MULTILAYER CERAMIC CAPACITORS Mohammadreza Keimasi, Doctor of Philosophy, 2007 Dissertation directed by: Professor Michael Pecht Department of Mechanical Engineering Multilayer ceramic capacitors (MLCCs) are known to be susceptible to cracking when subjected to excessive printed circuit board (PCB) flexu...

The additive manufacturability of nickel-based superalloys for laser powder bed fusion (LPBF) technologies is studied by considering the in-process cracking mechanisms. largely depends on resistance to liquid and solid-state cracking. Herein, we propose a two-parameter-based, heat deformation (HR-DR) model, accounting relation between chemical composition (both major minor elements) susceptibil...

Surface chemical and morphological modifications of as-plated Cr(III)-passivated monophasic zinc-nickel coatings induced by corrosion in chloride solutions are demonstrated. The passivated samples showed slower anodic dissolution, less significant de-alloying, smaller surface dezincification lower coating cracking, as demonstrated Scanning Electron Microscopy Energy Dispersive X-ray Spectroscop...

Although solidification cracking is not usually regarded as a serious problem when welding ferritic steels, improvements in the submerged arc welding process, using higher deposition rates and faster welding speeds, have led to welding conditions more likely to give cracking. Furthermore, the need to weld stronger tougher steels, where the inspection requirements are more stringent, has led to ...

Citation: Bellingeri M, Quilot-Turion B, Oliveira Lino L and Bevacqua D (2018) The Crop Load Affects Brown Rot Progression in Fruit Orchards: High Fruit Densities Facilitate Fruit Exposure to Spores but Reduce the Infection Rate by Decreasing Fruit Growth and Cuticle Cracking. Front. Ecol. Evol. 5:170. doi: 10.3389/fevo.2017.00170 The Crop Load Affects Brown Rot Progression in Fruit Orchards: H...