UNLABELLED Aerosol drug delivery via high flow nasal cannula (HFNC), bubble continuous positive airway pressure (CPAP), and synchronized inspiratory positive airway pressure (SiPAP) has not been quantified in spontaneously breathing premature infants. OBJECTIVES The purpose of this study was to compare aerosol delivery via HFNC, bubble CPAP, and SiPAP in a model of a simulated spontaneously b...

STUDY OBJECTIVES Evidence suggests that, to maintain treatment effects, nasal continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA) needs to be used every night. What remains unknown is the nightly duration of use required to normalize functioning. This study, employing probit analyses and piecewise regression to estimate dose-response functions, estimated likelih...

Treatment of obstructive sleep apnea with nasal continuous positive airway pressure mandates simultaneous increases of both inspiratory and expiratory positive airway pressures to eliminate apneas as well as nonapneic oxyhemoglobin desaturation events. We hypothesized that the forces acting to collapse the upper airway during inspiration and expiration are of different magnitudes and that obstr...

Obstructive sleep apnea (OSA) is defined by quantifying apneas and hypopneas along with symptoms suggesting sleep disruption. Subtler forms of sleep-disordered breathing can be missed when this criteria is used. Newer technologies allow for non-invasive detection of flow limitation, however consensus classification is needed. Subjects with flow limitation demonstrate electroencephalogram change...

OBSTRUCTIVE SLEEP APNOEA SYNDROME (OSAS) IS A COMMON MEDICAL DISORDER AFFECTING 2% TO 4% OF THE ADULT MIDDLE-AGED POPULATION.1 Recent studies have suggested that even patients with mild breathing abnormalities during sleep (apnoea-hypopnoea index, [AHI] < 15) may have associated hypertension,2 neurocognitive deficits,3 and excessive daytime sleepiness leading to an increased risk of motor vehic...

Abstract Biopsies of the palate are generally well-tolerated with known complications pain, bleeding, or infection, that can usually be well-controlled. We report a case 63-year-old male who developed rare complication following biopsy an ulcer on junction between hard and soft palate. Despite uneventful routine biopsy, patient presented oro-nasal fistula complaints nasal discharge. The cause w...

The difference between mean inspiratory and expiratory respiratory reactance (delta(rs)) measured with forced oscillation technique (FOT) at 5 Hz allows the detection of expiratory flow limitation (EFL) in chronic obstructive pulmonary disease (COPD) patients breathing spontaneously. This aim of this study was to evaluate whether this approach can be applied to COPD patients during noninvasive ...