Submit Manuscript | http://medcraveonline.com Abbreviations: AhR: Aryl Hydrocarbon Receptor; Arnt: Nuclear Translocator; CLP: Cecal Ligation and Puncture; CVB3: Coxsackievirus B3; CRP: C-Reactive Protein; CYP-450: Cytochrome P-450; ECOD: Ethoxycoumarin O-Deethylase; GH: Growth Hormone; IMND: Imipramine N-Demethylase; iNOS: inducible Nitric Oxide Synthetase; icv: intracerebroventricularly; IFN-γ...

Cerebrospinal fluid samples collected from 23 children with neurologic symptoms, such as febrile seizures, status epilepticus, and transient altered states of consciousness, associated with acute febrile illness, were examined for infectious virus by cell culture. Enteroviruses (echovirus type 9 and coxsackievirus B3) were isolated from 2 of the cerebrospinal fluid samples. The samples were als...

Abstract Haplophyllum tuberculatum is a plant commonly used in folk medicine to treat several diseases including vomiting, nausea, infections, rheumatism, and gastric pains. In the current study, H. essential oils, hydrosols, pure compounds R-(+)-limonene, S-(−)-limonene, 1-octanol, as well their combinations R-(+)-limonene/1-octanol S-(−)-limonene/1-octanol, were screened for cytotoxicity on H...

Zajac, Ihor (Hahnemann Medical College, Philadelphia, Pa.), and Richard L. Crowell. Location and regeneration of enterovirus receptors of HeLa cells. J. Bacteriol. 89:1097-1100. 1965.-Treatment of live HeLa cells with chymotrypsin or trypsin completely inactivated the viral receptors for coxsackievirus B3 and poliovirus T1, respectively. Enzyme-treated cells regained their enterovirus receptor ...

We examined the ability of small interfering RNAs (siRNAs) to disrupt infection by coxsackievirus B3 (CVB3). The incorporation of siRNAs dramatically decreased cell death in permissive HeLa cells in parallel with a reduction in viral replication. Three of four siRNAs had potent anti-CVB3 activity. The present study thus demonstrates that the antiviral effect is due to the downregulation of vira...

T he study by Davidoff and colleagues in this issue of Circulation' is helpful because it establishes clinically useful distinctions between two forms of myocarditis. In thinking about etiologies of myocarditis, I find it helpful to consider six categories. The first, viral myocarditis, is caused by ongoing myocardial infection, such as by coxsackievirus B3 or mumps virus. All other infectious ...

Amiloride and its derivative 5-(N-ethyl-N-isopropyl)amiloride (EIPA) were previously shown to inhibit coxsackievirus B3 (CVB3) RNA replication in cell culture, with two amino acid substitutions in the viral RNA-dependent RNA polymerase 3D(pol) conferring partial resistance of CVB3 to these compounds (D. N. Harrison, E. V. Gazina, D. F. Purcell, D. A. Anderson, and S. Petrou, J. Virol. 82:1465-1...