Currently, there had been a worldwide growing interest in gene therapy, being the most sustainable therapeutic approach for cancers as well as genetic diseases for upcoming 50 years and beyond.1‒5 Furthermore, several researchers have reported that we can conduct a programmable editing of a target base in genomic DNA without double-stranded DNA cleavage5 and even further to this we can conduct ...

A 34-year-old pregnant Turkish woman was admitted to the emergency service because of contractions at 33 weeks. Her vaginal examination revealed 8-9 cm cervical dilatation and 80-90% effacement. Fetal membranes were intact, and the fetus had a vertex presentation. Shortly after, she had a vaginal delivery. The newborn had mid-facial cleft, low-set ears, cleft lip, bilateral pterygia, ambiguous ...

The metabolism of albumin and IgG was investigated in two siblings, products of a first-cousin marriage, a female aged 34 yr and a male aged 17, who had a marked reduction in their respective serum concentrations of IgG (1.3 and 3.1 mg/ml) and albumin (19 and 21 mg/ml). The metabolism of radioiodinated IgG and albumin was studied in the two patients. The total circulating and body pools of IgG ...

Age at first marriage has risen dramatically since the mid-1960s among a wide spectrum of the U.S. population. Researchers have considered many possible explanations for this trend. Few, though, have asked why individuals should want to delay marriage in the first place. One possibility is that early marriage inhibits the career development of one or both individuals in a marriage. We test this...

BACKGROUND Marriage histories are a valuable data source for investigating nuptiality. While researchers typically acknowledge the problems associated with their use, it is unknown to what extent these problems occur and how marriage analyses are affected. OBJECTIVE This paper seeks to investigate the quality of marriage histories by measuring levels of misreporting, examining the characteris...

Introduction: The Thiamine Transporter gene SLC19A2 is the only gene known to be associated with TRMA.  This syndrome is a trial clinical characterized by megaloblastic anemia, nonautoimmune diabetes mellitus and sensory-neural hearing loss. Methods: Described here are three children from consanguineous Iranian families with thiamine – responsive megaloblastic anemia (TRMA) or Rogers' syndrome....