With the advent of powerful computers, vehicle safety issues have recently been addressed using computational methods of vehicle crashworthiness, resulting in reductions in cost and time for new vehicle development. Vehicle design demands multidisciplinary optimization coupled with a computational crashworthiness analysis. However, simulation-based optimization generates deterministic optimum d...

Fulfilling the growing water demand, at domestic, industrial and agriculture level, is the most challenging task and groundwater plays the most important role for achieving this demand. In this scenario, proper management of groundwater resources is the most required act, as unmanaged groundwater extraction may cause shrinking of aquifer, sea water intrusion and water quality problems. The simu...

An overview of the current capabilities and limitations of molecular simulation of biomolecular complexes in the context of computer-aided drug design is provided. Steady improvements in computer hardware coupled with more refined representations of energetics are leading to a new appreciation of the driving forces of molecular recognition. Molecular simulations are poised to more frequently gu...

Scheduling elective surgeries is a complicated task due to the coupled effect of multiple sources of uncertainty and the impact of the proposed schedule on the downstream units. In this paper, we propose an adaptive robust optimization model to address the existing uncertainty in surgery duration and lengthof-stay in the surgical intensive care unit. The framework allows for the decision-maker ...

This paper introduces a software architecture which can help that Internet-based collaboration in the field of system design becomes reality. Today many powerful tools for simulation, synthesis, test, and optimization are available. But most of them can only work as stand-alone tool on a certain platform. With MOSCITO these design tools can be encapsulated and coupled via Internet. Design engin...

Designing a low cost, survivable, telecommunications network is an extremely complicated process. Most commercial products available to help with this process are based on simulation and/or proprietary heuristics. However, there is a growing consensus that mathematical programming belongs in the designer’s “toolkit.” Easyto-use modeling languages coupled with powerful optimization solvers have ...

The prevalent strategy in the topology optimization phase is to select a subset of members existing in an excessively connected truss, called Ground Structure, such that the overall weight or cost is minimized. Although finding a good topology significantly reduces the overall cost, excessive growth of the size of topology space combined with existence of varied types of design variables challe...