OBJECTIVE Data on the impact of PAI-1-675 4G/5G genotype for fibrinolysis during myocardial infarction are inconsistent. The aim of our study was to evaluate the association of clinical and genetic (PAI-1-675 4G/5G polymorphism) factors with coronary artery occlusion in patients with myocardial infarction. MATERIALS AND METHODS PAI-1-675 4G/5G detection was achieved by using Sanger sequencing...

Creatine kinase (CK) isoenzymes MM, MB, and BB are located primarily in the cell cytosol, and increased CKMB in plasma is the hallmark of myocardial infarction. However, whether CK is released with reversible ischemic injury remains controversial. Here, we assessed plasma CK activity--cytosolic and mitochondrial CK--in serial samples (every 10 min for 60 min, then hourly or every 4 h for 48 h) ...

Coronary collaterals may not be apparent during routine coronary angiography or during coronary angioplasty as a result of a variety of physiologic and anatomic factors.‘-” The dynamic nature of the collateral circulation has been demonstrated by newly appearing angiographic collaterals during contralateral vessel occlusion.3 An elevated coronary occlusion wedge pressure during angioplasty ball...

A 50 yr old female developed transient ST segment elevation due to an acute coronary vasospasm following a Indian Red Scorpion sting and the angiogram revealed 50% occlusion in right coronary artery (RCA).The possible mechanism is that the sympathetic over-activity could have aggravated the occlusion in the RCA as the RCA is more commonly prone to spasm compared to the other coronary arteries.

The retrograde approach is a novel technique of percutaneous coronary intervention for chronic total occlusion. This technique has improved the success rate of guidewire passage through the occlusion. In the retrograde approach, a microcatheter and balloon are delivered through a retrograde channel. However, it is difficult for a stent to pass through collateral arteries. We report a case of co...

The effect of abrupt coronary artery occlusion on regional left ventricular (LV) function is well known, but serial changes in circumferential regional function over the first few hours have not been extensively investigated. Circumflex coronary artery occlusion was produced in nine closed-chest, conscious dogs and changes in LV circumferential function were assessed using two-dimensional echoc...

Hypothermic synchronized retroperfusion (HSRP) was applied in closed-chest dogs after acute coronary occlusion to determine whether this intervention can significantly retard the otherwise rapidly developing irreversible ischemic injury. The left anterior descending coronary artery (LAD) was occluded for 3 hours in 22 dogs and for 6 hours in 16 dogs. Starting 30 minutes after occlusion, HSRP wa...

UNLABELLED Conventional myocardial perfusion PET tracers require onsite tracer production because of their short radioactive half-lives. To investigate the potential of a new (18)F-labeled pyridazinone analog ((18)F-BMS-747158-02), we characterized this tracer in a rat model of permanent and transient coronary occlusion using small-animal PET. METHODS Myocardial (18)F-BMS-747158-02 distributi...

We report a case of a postinfarction ventricular septal defect caused by an acute recurrent occlusion after the implantation of a covered stent, which was performed as a rescue procedure for the ruptured left anterior descending artery during a percutaneous coronary intervention. Although the emergent implantation of a covered stent for the ruptured coronary arteries such as the left main coron...

Chronic total occlusion of an anomalous right coronary artery arising from left coronary sinus is uncommon. We are describing a case of a 71 years old patient presented with severe chest pain along with exertional dyspnea with an inferior wall myocardial infarction. Coronary angiography showed anomalous right coronary artery originating from left coronary sinus having chronic total occlusion in...