For several decades, pathologists observed that coronary atherosclerosis is generally limited to subepicardial segments and that intramyocardial coronary segments rarely show atherosclerosis. They also observed that pericardial fat is primarily located along the main coronary branches. These 2 observations led investigators to suspect and confirm a relationship between pericardial fat and coron...

We histologically examined the coronary arteries of 52 autopsied cases of the youths (3 to 39 years of age, mean 28.5 years) in Kyushu island, Japan, without clinical events of coronary artery diseases. The coronary artery specimens were taken from the proximal portions of the right coronary artery (Seg. 1), the left anterior descending artery (Seg. 6), and the macroscopically most stenotic reg...

Human blood groups ABO (BG) represent an important system in transfusion medicine and transplantation, have a role the development of heart disease. The current study was conducted with aim comparing types knowing most affected by atherosclerosis type 2 diabetes. Our consisted total (n192) population age range (45-70) years old overweight terms their BMI. first group included (n64) under Prec...

background and objectives: cardiovascular disease is the most common cause of death in developed countries. in addition to traditional risk factors for cardiovascular disease, nowadays, accumulating evidence indicates that a variety of infections contribute to pathogenesis of atherosclerosis,  (we investigated whether helicobacter pylori infection is related to prevalence of coronary heart dise...

OBJECTIVE The degree of subclinical coronary atherosclerosis in HIV-infected patients is unknown. We investigated the degree of subclinical atherosclerosis and the relationship of traditional and nontraditional risk factors to early atherosclerotic disease using coronary computed tomography angiography. DESIGN AND METHODS Seventy-eight HIV-infected men (age 46.5 +/- 6.5 years and duration of ...

BACKGROUND Most of our knowledge about atherosclerosis at young ages is derived from necropsy studies, which have inherent limitations. Detailed, in vivo data on atherosclerosis in young individuals are limited. Intravascular ultrasonography provides a unique opportunity for in vivo characterization of early atherosclerosis in a clinically relevant context. METHODS AND RESULTS Intravascular u...

Background—Most of our knowledge about atherosclerosis at young ages is derived from necropsy studies, which have inherent limitations. Detailed, in vivo data on atherosclerosis in young individuals are limited. Intravascular ultrasonography provides a unique opportunity for in vivo characterization of early atherosclerosis in a clinically relevant context. Methods and Results—Intravascular ult...

Systemic and local inflammation plays a prominent role in the pathogenesis of atherosclerotic coronary artery disease, but the relationship of whole blood gene expression changes with coronary disease remains unclear. We have investigated whether gene expression patterns in peripheral blood correlate with the severity of coronary disease and whether these patterns correlate with the extent of a...