Diagnosing and selecting an appropriate treatment strategy for left main coronary artery (LMCA) obstruction is very important. Although this disease is not frequently encountered, it can cause severe hemodynamic deterioration resulting in a less favorable prognosis without a suitable management approach. Another aspect of LMCA that we must not overlook is coronary artery spasm, which can be an ...

Background. Coronary spasm may be caused by endothelial dysfunction, vascular smooth muscle hyperreactivity, or both. We aimed to determine the relative role of endothelial dysfunction and vascular smooth muscle hyperreactivity in the pathogenesis of coronary artery spasm in the swine model in vivo. Methods and Results. In G6ttingen miniature pigs given a high cholesterol diet, a segment of the...

Introduction Acute coronary stenosis has been reported as a rare but potentially serious complication of cavotricuspid isthmus (CTI) ablation. Various causes of the stenosis have been reported (thrombus, coronary spasm), but cause is often unknown. Most of the cases receive coronary intervention regardless of the cause. We present a case of “temporary edema” of the coronary artery wall provoked...

Recurrent ST-segment elevations in leads where new Q waves developed were repeatedly recorded in six patients during a recovery phase of acute myocardial infarction. Such ST-segment elevations were transient, occurred with or without chest pain, and returned to control levels. No enzymatic changes signifying recurrent myocardial necrosis were found after each episode. Selective coronary cineang...

Seven patients with typical variant angina without coronary stenoses greater than 50% developed angina and ST-segment elevation during treadmill exercise testing. In all cases the ST-segment elevation occurred in the same leads during exercise testing as during spontaneous attacks at rest. Five of the patients had developed spontaneous coronary spasm during coronary arteriography, in each case ...

To assess whether coronary spasm affects the progression of atherosclerosis and results in evolution of myocardial infarction, the role of coronary spasm on the fine structure of conduit coronary arteries was studied morphologically. Göttingen miniature pigs were fed a semisynthetic diet containing 2% cholesterol and 1.1% sodium cholate. One month after being on this diet, the pigs were anesthe...

AIMS Provocation tests of coronary artery spasm are useful for the diagnosis of vasospastic angina (VSA). However, these tests are thought to have a potential risk of arrhythmic complications, including ventricular tachycardia (VT), ventricular fibrillation (VF), and brady-arrhythmias. We aimed to elucidate the safety and the clinical implications of the spasm provocation tests in the nationwid...

5-FU was discontinued. Previous reports have identified angina1 symptoms as a rare symptom of 5-FU cardiac toxicity.1-5 Some of these patients had also undergone irradiation4 of the left ventricle or had coronary artery disease.‘s3 Underwood et a1.6 suggested coronary artery spasm as a possible mechanism of toxicity. Other proposed mechanisms have included an autoimmune response and inflammator...

1182 Communications to the Editor 2 SeIzer A, Langstom M, Ruggeroli C, Cohn K. Clinical syndrome of variant angina with normal coronary arteriogram. N Engi J Med 1976; 295:1343-47 3 Yasue H. Pathophysiology and treatment of coronary arterial spasm. Chest 1980; 78 (suppl):216-23 4 Miller DD, Waters DD, Dangoisse V. David PR. Symptomatic coronary artery spasm following radiotherapy for HOdgkin di...