نتایج جستجو برای: coronary arteries disease

تعداد نتایج: 1625893  

Introduction: Atherosclerosis is an inflammatory disease and is one of the leading causes of cardiovascular disease. Vascular plaques are formed on the inner surface of hardened arteries and gradually develop, reducing the diameter of the arteries. CXCR4 is one of the most important chemokine receptors, whose presence has been confirmed in cardiac plaques. Our aim was to determine the relations...

Journal: :Circulation 1998
S Allen M Dashwood K Morrison M Yacoub

BACKGROUND Leukotrienes are a class of biologically active lipids that have potent effects on the heart. To assess their role in coronary artery disease, we compared the contractile responses of leukotriene C4 (LTC4) and leukotriene D4 (LTD4) and their binding activity in both atherosclerotic and nonatherosclerotic human coronary arteries. We also studied expression of the enzymes that control ...

Journal: :Journal of physics 2023

Abstract Coronary heart disease is caused by narrowing or obstruction of the arteries that supply blood to muscle. In establishing a diagnosis disease, precise and accurate radiological examination required. Parameters are needed in Computed Tomography (CT) angiography support with radiation safety. This research qualitative study an observational survey approach was conducted at Hospital Semar...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2003
Patrick J Gavin Susan E Crawford Stanford T Shulman Francesca L Garcia Anne H Rowley

OBJECTIVE Coronary artery aneurysms are the major complication of Kawasaki disease (KD). Matrix metalloproteinases (MMPs) regulate remodeling and degradation of the extracellular matrix. We hypothesized that MMP-9 expression is increased in acute KD aneurysms when compared with KD nonaneurysmal arteries and arteries from control children. METHODS AND RESULTS MMP-2, MMP-9, tissue inhibitor of ...

2015
Carlos Alexandre Wainrober Segre Whady Hueb Rosa Maria Rahmi Garcia Paulo Cury Rezende Desiderio Favarato Celia Maria Cassaro Strunz Marília da Costa Oliveira Sprandel Alessandra Roggério Ana Luiza de Oliveira Carvalho Raul Cavalcante Maranhão José Antonio Franchini Ramires Roberto Kalil Filho

BACKGROUND Cardiac-specific troponin detected with the new high-sensitivity assays can be chronically elevated in response to cardiovascular comorbidities and confer important prognostic information, in the absence of unstable coronary syndromes. Both diabetes mellitus and coronary artery disease are known predictors of troponin elevation. It is not known whether diabetic patients with coronary...

2015
Maria S. Nazarenko Anton V. Markov Igor N. Lebedev Maxim B. Freidin Aleksei A. Sleptcov Iuliya A. Koroleva Aleksei V. Frolov Vadim A. Popov Olga L. Barbarash Valery P. Puzyrev

Epigenetic mechanisms of gene regulation in context of cardiovascular diseases are of considerable interest. So far, our current knowledge of the DNA methylation profiles for atherosclerosis affected and healthy human vascular tissues is still limited. Using the Illumina Infinium Human Methylation27 BeadChip, we performed a genome-wide analysis of DNA methylation in right coronary artery in the...

2017
T. S. de Lange R. Y. G Tijssen P. Damman P. F. M. M. van Bergen

BACKGROUND An important number of patients with suspected cardiac chest pain have non-obstructive coronary artery disease. Our purpose was to describe the clinical characteristics of patients with normal or near-normal coronary arteries in routine cardiological practice in a secondary care hospital. METHODS In 2013, consecutive patients referred for invasive coronary angiography with suspecte...

Journal: :Reviews in cardiovascular medicine 2006
Norman E Lepor

Computed tomographic coronary angiography (CTCA) can assist with the diagnosis of a variety of cardiovascular disorders. The rationale for performing screening CTCA is to define the presence, absence, and severity of coronary artery disease, particularly in those patients who are categorized to be at intermediate risk by conventional risk factor assessment for a cardiovascular event. In additio...

Journal: :research in cardiovascular medicine 0
hamidreza sanati cardiovascular intervention research center, rajaie cardiovascular medical and research center, tehran university of medical sciences, tehran, ir iran ali zahedmehr cardiovascular intervention research center, rajaie cardiovascular medical and research center, tehran university of medical sciences, tehran, ir iran ata firouzi cardiovascular intervention research center, rajaie cardiovascular medical and research center, tehran university of medical sciences, tehran, ir iran; cardiovascular intervention research center, rajaei cardiovascular medical and research center, vali-asr ave., niyayesh blvd, tehran, ir iran, tel: +98-9126782019, fax: +98-2122663335 negar salehi cardiovascular intervention research center, rajaie cardiovascular medical and research center, tehran university of medical sciences, tehran, ir iran mohsen maadani cardiovascular intervention research center, rajaie cardiovascular medical and research center, tehran university of medical sciences, tehran, ir iran farshad shakerian cardiovascular intervention research center, rajaie cardiovascular medical and research center, tehran university of medical sciences, tehran, ir iran

conclusions: patent coronaries of ua/nstemi patients have a trend to higher tfcs compared to normal values. presence of significant coronary lesions in these patients significantly increases tfc. objectives: the present study is aimed to measure the tfc in the coronary arteries of ua/nstemi patients to find abnormalities in diseased or patent vessels and compare with the normal values. patients...

Journal: :Journal of pharmacological sciences 2005
Yasushi Horai Ken-Ichi Furukawa Shingo Iwata Yasushi Ohizumi

Stricture of coronary arteries is closely related to ischemic heart disease. The purpose of this study was to examine whether changes in pH caused contraction of rat coronary arteries, as determined using Langendorff perfused hearts. Changing the pH of the perfusate increased perfusion pressure as an indication of the contractile state of coronary arteries. Alkaline pH-induced increase of perfu...

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