Purpose To report a case of endothelial keratoplasties (EKs) performed in a 4 month old with a posterior polymorphous corneal dystrophy. Observations A 4 month old infant underwent Descemet membrane endothelial keratoplasty (DMEK) for posterior polymorphous corneal dystrophy. The graft was found to be dislocated on day 5 post-operatively and an attempt to unfold the DMEK scroll and re-bubble ...

Aim: To determine the disease causing gene defects in two patients with Meesmann’s corneal dystrophy. Methods: Mutational analysis of domains 1A and 2B of the keratin 3 (K3) and keratin 12 (K12) genes from two patients with Meesmann’s corneal dystrophy was performed by polymerase chain reaction amplification and direct sequencing. Results: Novel mutations of the K12 gene were identified in both...

Published descriptions of families with lattice dystrophy of the cornea reveal a much more varied clinical course and a more pleomorphic corneal picture than the rather stereotyped textbook descriptions would suggest. This report describes a family with lattice dystrophy of unusually late onset with retention of useful vision into the 7th decade. Herpes simplex keratitis was misdiagnosed in 5 m...

Normal, scarred, and dystrophic corneas were histochemically probed with a panel of 16 lectins by means of an avidin-biotin revealing system. Normal corneal epithelial cells, keratocytes, and endothelial cells expressed at least two distinct N-linked oligosaccharide subsets, of the non-bisected, biantennary and bisected, bi-/triantennary types. Corneal scars stained variably with the lectin sub...

OBJECTIVE To evaluate the use and complications of a penetrating keratoprosthesis implantation in the management of corneal opacification in dogs. METHODS A retrospective clinical study describes the indications for the surgical technique utilized and the outcomes of this procedure in 20 eyes of 19 dogs with blindness of corneal origin. A successful surgical outcome was defined as a clear ker...

Three genetic corneal dystrophies [congenital hereditary endothelial dystrophy type 2 (CHED2), Harboyan syndrome and Fuchs endothelial corneal dystrophy] arise from mutations of the SLC4a11 gene, which cause blindness from fluid accumulation in the corneal stroma. Selective transmembrane water conductance controls cell size, renal fluid reabsorption and cell division. All known water-channellin...

Experience is described of 150 cases in which an intraocular lens of the Binkhorst (iris clip and iridocapsular type) was introduced after cataract extraction. The most serious complications are dislocation and corneal dystrophy.

Corneal diseases are one of the major causes of blindness worldwide. Conservative medical agents, which may prevent sight-threatening corneal disease progression, are urgently desired. Numerous evidences have revealed the involvement of oxidative stress in various corneal diseases, such as corneal wound healing and Fuchs endothelial corneal dystrophy (FECD). Nuclear factor (erythroid-derived 2)...

Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang Univ Abbreviations and Acronyms: CDS 1⁄4 Cornea Donor Study; DMEK 1⁄4 Descemet membrane endothelial keratoplasty; DSEK 1⁄4 Descemet stripping endothelial keratoplasty; ECD 1⁄4 endothelial cell density; EK 1⁄4 endothelial keratoplasty; FECD 1⁄4 Fuchs’ endothelial corneal dystrophy; MCMC 1⁄4 Markov chain Monte Carlo; PACE 1⁄4 pseudo...