Performance on multicore processors is determined largely by on-chip cache. Computer architects have conducted numerous studies in the past that vary core count and cache capacity as well as problem size to understand impact on cache behavior. These studies are very costly due to the combinatorial design spaces they must explore. Reuse distance (RD) analysis can help architects explore multicor...

Sigma factors control global switches of the genetic expression program in bacteria. Different sigma factors compete for binding to a limited pool of RNA polymerase (RNAP) core enzymes, providing a mechanism for cross-talk between genes or gene classes via the sharing of expression machinery. To analyze the contribution of sigma factor competition to global changes in gene expression, we develo...

In the S project, core calculi have been adopted as a linguistic means to model and analyze service oriented applications. The present chapter reports about the static analysis techniques developed for the S sessionoriented core calculi CaSPiS and CC. In particular, it presents a type system for client progress and control flow analysis in CaSPiS and type systems for conversation ...

The multiprotein Mediator complex has been shown to interact with gene-specific regulatory proteins and RNA polymerase II in vitro. Here, we use chromatin immunoprecipitation to analyze the recruitment of Mediator to GAL genes of yeast in vivo. We find that Mediator associates exclusively with transcriptionally active and not inactive GAL genes. This association maps to the upstream activating ...

We analyze ROSAT HRI observations obtained from 1992 to 1996 of the globular cluster 47 Tuc. Identifications of two X-ray sources with HD 2072 and with a galaxy, respectively, are used to obtain accurate (< 2′′) positions of the X-ray sources in the cluster. We find possible optical counterparts, including the blue objects V 1 and V 2, for three X-ray sources in the core of 47 Tuc, but note tha...