In burn patients, scar contractures adjacent to or across the joints lead to disabling deformities. In Dupuytren's disease, the proliferative process involves the fascia of the palm and fingers, resulting in disabling flexion contractures of the fingers and the palm. A single insult involving the hand or even a more proximal injury may lead to Dupuytren's disease.

Peri-anal contracture lead to intestinal obstruction whenever there is involvement of anal orifice. In this case anus and peri-anal skin up to two cm was normal; however both gluteal folds were fused because of post burn scar leaving a very small opening which lead to faecal impaction and sub acute intestinal obstruction.

OBJECTIVE Spinal cord injury results in loss of neurons, degeneration of axons, formation of glial scar, and severe functional impairment. Human umbilical cord mesenchymal stem cells can be induced to form neural cells in vitro. Thus, these cells have a potential therapeutic role for treating spinal cord injury. DESIGN AND SETTING Rats were randomly divided into three groups: sham operation g...

Cutaneous squamous cell carcinoma is a malignant tumour of the keratinising cells epidermis or its appendages. It constitutes 20% skin malignancy. UV radiation exposure most common cause cancer with sun exposed face and upper trunk being site for occurrence. Long term to chemical carcinogen, burn scar, chronic ulcer among other risk factors. Skin biopsy mainstay diagnosis in suspected lesion SC...

The miombo woodlands of southern Africa are one of the most extensively burned biomes in the tropics. The detectability of understory burns in these woodlands was assessed with a sensitivity analysis approach, based on a hybrid geometrical–optical radiative transfer model. Model input data were obtained from a variety of sources, including field biometry and spectroradiometry, and satellite dat...

BACKGROUND Severe burns result in hypercatabolic state and concomitant muscle atrophy that persists for several months, thereby limiting patient recovery. However, the effects of burns on the corresponding spinal dermatome remain unknown. This study aimed to investigate whether burns induce apoptosis of spinal cord ventral horn motor neurons (VHMNs) and consequently cause skeletal muscle wastin...

The inflammatory response in the injured spinal cord, an immune privileged site, has been mainly associated with the poor prognosis. However, recent data demonstrated that, in fact, some leukocytes, namely monocytes, are pivotal for repair due to their alternative anti-inflammatory phenotype. Given the pro-inflammatory milieu within the traumatized spinal cord, known to skew monocytes towards a...

Hands are the most frequent sites of burn injury, complications after thermal hand injury include and proper management is essential to assure that optimal functional recovery is achieved. Although each hand represents less than 3% of the total body surface area, burns to the hand are considered serious injuries and should be referred to a burn center. The thin, highly mobile dorsal skin, the s...

UNLABELLED Burn injuries in the United States account for over one million hospital admissions per year, with treatment estimated at four billion dollars. Of severe burn patients, 30-90% will develop hypertrophic scars (HSc). In this study, we evaluate the impact of an elastomeric, randomly-oriented biostable polyurethane (PU) scaffold on HSc-related outcomes. In vitro, fibroblast-seeded PU sca...

Scarring is a significant medical burden; financially to the health care system and physically and psychologically for patients. Importantly, there have been numerous case reports describing the occurrence of cancer in burn scars. Currently available therapies are not satisfactory due to their undesirable side-effects, complex delivery routes, requirements for long-term use and/or expense. Radi...