OBJECTIVE To analyze plasma myostatin levels and investigate their relationship with right ventricular (RV) function in patients with cor pulmonale secondary to chronic obstructive pulmonary disease (COPD). METHODS The study recruited 81 patients with advanced COPD and 40 age-matched controls. The patients were divided into two groups: those with cor pulmonale and those without. Echocardiogra...

We have recently reported that PML-RAR-induced misfolding of the N-CoR protein could be reversed by retinoic acid (RA), a therapeutic agent that promotes differentiation of acute promyelocytic leukemia (APL) cells. This finding suggests a role of misfolded N-CoR in the differentiation arrest of APL cells and highlights its significance as a potential molecular target in protein conformation-bas...

Figure 1 – A) Transthoracic echocardiogram showing cor triatriatum: proximal and distal left atrium separated by a membrane (Pointing white arrow), LA: left atrium; LV: left ventricle; RV: right ventricle; RA: right atrium. B) Transesophageal echocardiogram showing cor triatriatum: proximal and distal left atrium separated by a membrane (Pointing white arrow), LA: left atrium; LV: left ventricl...

in hilbert space l2(rn), we prove the equivalence between the mod-ulus of smoothness and the k-functionals constructed by the sobolev space cor-responding to the fourier transform. for this purpose, using a spherical meanoperator.

PURPOSE To comprehensively assess the reliability of automated Pentacam (Oculus, Inc.) measurements. SETTING Flinders Eye Centre, Flinders Medical Centre, Bedford Park, South Australia, Australia. METHODS Both eyes of 35 normal volunteers were tested twice on the same day by 2 different observers. All automated values were recorded, and manual analysis of topographic maps was performed only...

AIM To compared outcomes between the hypothenar fat pad flap (HTFPF) and conventional open carpal tunnel release (COR) in primary carpal tunnel syndrome (CTS). METHODS Forty-five patients (49 hands) were enrolled into the study from January 2014 to March 2016, 8 patients were excluded. Randomization was conducted in 37 patients (41 hands) by computer generated (Block of four randomization) in...

OBJECTIVES In recent years there has been increasing emphasis on the mental health aspects of primary health care for children and adolescents. The Health Resources and Services Administration's Maternal and Child Health Bureau has contributed to efforts aimed at strengthening primary care not only in early identification and beginning intervention with mental disorders, but also in prevention ...

With the purpose of improving the performance of next generation wireless networks, cooperative relaying (CoR) and network coding (NC) are promising techniques. The number of time slots required for NC in bidirectional transmission is less than that required for CoR, and hence, NC can achieve higher throughput performance than CoR. However, the disadvantage of NC is that asymmetric traffic rati...

Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood pressure. In cardiomyocytes, the hormone is synthesized as a precursor, proatrial natriuretic peptide (pro-ANP), which is proteolytically converted to active ANP. Corin is a cardiac transmembrane serine protease that has been shown to process pro-ANP in vitro, but its physiological importance had not been established. He...

A growing body of evidence supports the coordination of pre-mRNA processing and transcriptional regulation. We demonstrate here that mammalian PRP4 kinase (PRP4K) is associated with complexes involved in both of these processes. PRP4K is implicated in pre-mRNA splicing as the homologue of the Schizosaccharomyces pombe pre-mRNA splicing kinase Prp4p, and it is enriched in SC35-containing nuclear...