Diet composition affects organismal health. Nutrient uptake depends on the microbiome. Caenorhabditis elegans fed a Bacillus subtilis diet live longer than those fed the standard Escherichia coli diet. Here we report that this longevity difference is primarily caused by dietary coQ, an antioxidant synthesized by E. coli but not by B. subtilis. CoQ-supplemented E. coli fed worms have a lower oxi...

Rigorous program development is notoriously difficult because it involves many aspects, among which specification, programming, verification, code reuse, maintenance, and version management. Besides, these various tasks are interdependent, requiring going back and forth between them. In this paper, we are interested in certain language features and in languages which help make the user’s life e...

BACKGROUND Coenzyme Q₁₀ (CoQ₁₀; also called ubiquinone) is an antioxidant that has been postulated to improve functional status in congestive heart failure (CHF). Several randomized controlled trials have examined the effects of CoQ₁₀ on CHF with inconclusive results. OBJECTIVE The objective of this meta-analysis was to evaluate the impact of CoQ₁₀ supplementation on the ejection fraction (EF...

Good tools can bring mechanical verification to programs written in mainstream functional languages. We use hs-to-coq to translate significant portions of Haskell’s containers library into Coq, and verify it against specifications that we derive from a variety of sources including type class laws, the library’s test suite, and interfaces from Coq’s standard library. Our work shows that it is fe...

This paper reports on the study of the quality costing practices at four large successful multinational companies. All four companies use systematic quality initiatives; however, a formal cost of quality (CoQ) methodology was only employed at one of them. This is in agreement with the literature findings arguing that a CoQ approach is not utilized in most quality management programs. The articl...

This paper presents the formal verification of a compiler front-end that translates a subset of the C language into the Cminor intermediate language. The semantics of the source and target languages as well as the translation between them have been written in the specification language of the Coq proof assistant. The proof of observational semantic equivalence between the source and generated c...

Teaching high-school mathematics using a general theorem prover becomes a reachable goal for the near future. In this article, we present a library dealing with geometry in Coq. This library is dedicated to high-school teaching. We stress on using a graphical interface and a drawing tool which ease the accessibility to formal statements. We present some significant examples of statements with f...

Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are effective drugs in the treatment of hypercholesterolemia, however, their undesirable actions are not fully known. We investigated the effects of atorvastatin on the oxidative phosphorylation and membrane fluidity in liver mitochondria, and also on the coenzyme Q (CoQ) content in the mitochondria, liver tissue,...

Large-scale software verification projects increasingly rely on proof assistants, such as Coq, to construct formal proofs of program correctness. However, such proofs must be checked after every change to a project to ensure expected program behavior. This process of regression proving can require substantial machine time, which is detrimental to productivity and trust in evolving projects. We ...

Mitoproteases are becoming recognized as key regulators of diverse mitochondrial functions, although their direct substrates are often difficult to discern. Through multi-omic profiling of diverse Saccharomyces cerevisiae mitoprotease deletion strains, we predicted numerous associations between mitoproteases and distinct mitochondrial processes. These include a strong association between the mi...