The accumulation of redox-active metal ions, in particular copper, in amyloid plaques is considered to the cause of the intensive oxidation damage to the brain of patients with Alzheimers disease (AD). Drug candidates based on a bis(8-aminoquinoline) tetradentate ligand are able to efficiently extract Cu(2+) from copper-loaded amyloids (Cu-Aβ). Contrarily, in the presence of a bidentate hydroxy...

Myxococcus xanthus is a soil-dwelling member of the δ-Proteobacteria that exhibits a complex developmental cycle upon starvation. Development comprises aggregation and differentiation into environmentally resistant myxospores in an environment that includes fluctuations in metal ion concentrations. While copper is essential for M. xanthus cells because several housekeeping enzymes use it as a c...

Complexes of 1,2,4-triazole (trz) and of the 1,2,4triazolate ion (trz') have been described before. Most of the papers dealt with copper compounds, especially CuCl2(trz), CuCl(trz')(H20 ) 2 and Cu(trz')2 1_n. J a r v i s 12 determined the structure of CuCl2(trz). It is a polynuclear complex, the copper ions being bridged by two chloride ions and a 1,2-bicoordinating triazole ligand. The linear ...

Z. Naturforsch. 55 b, 386-388 (2000); received February 10, 2000 Photochemistry, Copper(I), Uracil, Luminescence 1,3-Dimethyluracil (DMU) forms a complex with copper(I) iodide which shows a green luminescence at Amax = 505 nm. With PF6~ counter ions a photoactive Cu(I)DMU complex is generated which shows a long-wavelength absorption at Amax = 335 nm. Light absorption by this band leads to a dim...

A b st ra ct Ingestion of copper sulphate is an uncommon mode of poisoning in the Indian subcontinent. Cases are mainly suicidal in nature. The clinical course of the copper sulphate intoxicated patient is often complex involving intravascular hemolysis, jaundice and renal failure. The treatment is mainly supportive. In severe cases methemoglobinemia needs treatment. Mortality is quite high in ...

Transition metal ions in aqueous solutions generally exist as complex ions in which water molecules, acting as Lewis bases, "coordinate" or bond with the small cation (which acts as a Lewis acid). The water molecules in these structures are known as ligands. Historically this kind of attachment has been called either a coordinate covalent bond or a dative bond. The distinguishing characteristic...

Examination of a series of substituted bis(thiosemicarbazonato) copper(II) complexes shows that their reaction with Ehrlich ascites tumor cells can be understood in terms of the relative reactivity of the complexes with sulfhydryl groups. In general, the order of reactivity of the complexes correlates directly with their respective degrees of cytotoxicity and ability to inhibit DNA synthesis an...

The structure of [Cu(tpen)](ClO4)2 (tpen = N,N,N',N'-tetrakis(2-pyridylmethyl)-1,2-ethanediamine) has been identified by X-ray crystallography. The copper(II) ion is surrounded by two amine N atoms and three pyridine N atoms of the ligand, making a distorted trigonal-bipyramid. Among the six potential N donor atoms (two amine N and four pyridine N atoms), only one pyridine N atom remains uncoor...

Nicotinic acid (also known as vitamin B3) is a dietary element essential for physiological and antihyperlipidemic functions. This study reports the synthesis of novel mixed ligand complexes of copper with nicotinic and other select carboxylic acids (phthalic, salicylic and anthranilic acids). The tested copper complexes exhibited superoxide dismutase (SOD) mimetic activity and antimicrobial act...