Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. To investigate effect silymarin on chronic (COPD). The serum samples 20 healthy controls, patients with acute exacerbation COPD and stable were collected. LPS smoking used to induce mouse model. Our results showed that in COPD, O2-level release from peripheral blood neutrophils negatively correlated forc...

chronic obstructive pulmonary disease (copd) is one of the major causes of morbidity and mortality in adults. anemia is known as comorbidity in many chronic diseases that can increase morbidity and mortality of copd. recent studies have shown that anemia may be more prevalent than expected in copd patients and can increase disabilities of copd. in this study we have evaluated the correlation be...

Chronic Obstructive Pulmonary Disease (COPD) is a complex disease. Genetic, epigenetic, and environmental factors are known to contribute to COPD risk and disease progression. Therefore we developed a systematic approach to identify key regulators of COPD that integrates genome-wide DNA methylation, gene expression, and phenotype data in lung tissue from COPD and control samples. Our integrativ...

conclusions in short term, using the self-management program can lead to increased exercise tolerance and decreased dyspnea in patients with copd; thus, this program is recommended as an effective way to improve the functional statuses of these patients. results there was no significant difference between the groups in exercise tolerance at base line; but, they were significantly different at t...

  Background :Chronic obstructive pulmonary disease (COPD) is a third leading cause of death.   Methods : In this case control study, we prepared 5 cc bloods from the antecubital vein of 100 COPD patients and 40 healthy individuals as control group. Vascular endothelial growth factor (VEGF) expression protein level was measured by ELISA in both groups.   Results : We found that concentration of...

One of the major health challenges of the future is Chronic Obstructive Pulmonary Disease (COPD). It is characterized by airflow limitations, although current diagnosis does not give attention to the flow measurements. We aimed to develop a data-based model of the decline of the forced expiratory flow. Moreover, we analysed the relationship of model parameters with COPD presence and its severit...

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a disease characterized by airflow limitation and inflammation. Meanwhile, COPD also is associated with metabolic disorders, such as skeletal muscle weakness. Strikingly, activation of AMP-activated protein kinase (AMPK) exerts critical roles in energy metabolism. However, it remains unclear whether and how the expression levels of AMPK...

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible disease responsible for the deaths of 3 million people worldwide in 2005, and predicted to be the third leading cause of death worldwide by 2030. Many COPD models developed to date have followed a Markov structure, in which patients or populations can move between defined health states over successive time...

Recently, a Sendai virus (SeV) model of chronic obstructive lung disease has demonstrated an innate immune response in mouse airways that exhibits similarities to the chronic airway inflammation in human chronic obstructive pulmonary disease (COPD) and asthma, but the effect on distal lung parenchyma has not been investigated. The aim of our study is to image the time course and regional distri...

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function. The present study aimed to investigate the diaphragmatic protein expression of myostatin and its correlation with apoptosis in a rat model of CPOD. Sprague Dawley rats were randomly divided into a control group and a COPD group, the latter of which were exposed to cigarette...