Nitric oxide (NO) is known to be a neuromodulator with dual proconvulsive and anticonvul- sive action. Valeriana officinalis (VAL) was previously believed antiepileptic, but today as sedative sleep regulator. Seizures may associated abnormal electrocardio- graphic changes cardiac dysfunction arising from epilepsy related neuronal nitric (nNO). This study aimed investigate the effects of synthas...

Thyme with the scientific moniker of Thymus vulgaris has been used in traditional medicine for treatment respiratory and gastrointestinal disease. Its extract also adopted to treat epilepsy other central nervous system (CNS) disorders. To evaluate effect T. (TVE), experimental model memory impairment caused by seizures was performed rats. Seizures Wistar rats (200-250 g) were induced a challeng...

The effects of kindling of the right anterior medial amygdala of Wistar rats was studied. Kindling lastingly increased anxiety (decreased open-arm exploration) in the elevated plus-maze 1 week after the last kindled seizure, replicating previous findings. Changes in anxiety were independent of changes in exploration or activity in either the plus-maze or hole board. A new finding is the depende...

We have investigated excited-state electron transfer in a donor-bridge-acceptor complex containing phenothiazine (PTZ) linked via tris(meta-phenylene-ethynylene) to a tricarbonyl(bipyridine)(pyridine)Re(I) unit. Time-resolved luminescence experiments reveal two excited-state (*Re) decay regimes, a multiexponential component with a mean lifetime of 2.7 ns and a longer monoexponential component o...

OBJECTIVE Eclampsia is a poorly understood but potentially fatal complication of pregnancy. Research to date on this disorder has been hampered by the lack of a suitable animal model. To correct this deficiency, this report describes the generation of a rat eclampsia-like model using pentylenetetrazol (PTZ) in a previously established rat preeclampsia model. METHOD Rats were administered lipo...

An important role for oxidative stress both as a consequence and as a cause of epileptic seizures has been suggested. Since Achillea wilhelmsii (A. wilhelmsii) has been considered to have the antioxidant effects as well as central nervous system depressant properties, the anti-seizure effects of the plant extract in addition to its effects on brain tissues oxidative damage were investigated in ...

s | 21 Conclusions: Oleoylethanolamide modulates motivation of intra-gastric feeding, possibly through normalization of PPAR-αdependent vagal feedback to the brain in rodents. This supports its homeostatic function for regulating dietary fat intake via vagal-nigro-striatal pathways. Our study suggests that oleoylethanolamide mediates reward-associated neural processes and this signaling plays a...

The down-regulation of microRNA-328a (miR-328a) in pentylenetetrazole (PTZ)-kindled rats with memory impairment was demonstrated in our previous study, while any contribution of miR-328a to cognitive dysfunction of PTZ-kindled rats remains unknown. In this study we have investigated the effect and the underlying mechanism of miR-328a on the cognitive function in PTZ-kindled rats. 48 SD male rat...

The role of AMPA and GluR5-containing kainate receptors in the development and expression of amygdala kindling was examined using the selective 2,3-benzodiazepine AMPA receptor antagonist GYKI 52466 [(1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2, 3-benzodiazepine] and the decahydroisoquinoline mixed AMPA receptor and GluR5 kainate receptor antagonist LY293558 {(3S,4aR,6R, 8aR)-6-[2-(1(2)H...