BACKGROUND This randomized, double-blind study investigated the efficacy of continuous and patient-controlled ropivacaine infusion via a popliteal sciatic perineural catheter in ambulatory patients undergoing moderately painful orthopedic surgery of the foot or ankle. METHODS Preoperatively, patients (n = 30) received a posterior popliteal sciatic perineural catheter and nerve block. Postoper...

We have had this study to evaluate the clinical profile of target-controlled infusion-based anesthesia using remifentanil and propofol. 116 ASA I-II patients undergoing elective laparoscopic cholecystectomy (LCH) were enrolled. TCI Remifentanil was set at 8 micrograms. L - 1 as target and TCI propofol at 4 mcg/ml throughout the whole procedure. The hemodynamics during induction of anesthesia an...

Ketamine has been shown to be effective in treatment of episodes major depressive disorder (MDD). This controlled study aimed analyse the predictive and discriminative power heart rate (HR) variability (HRV) for ketamine MDD. In 51 patients, HR HRV were assessed at baseline before during infusion 24 hours post infusion. Montgomery–Åsberg Depression Rating Scale (MADRS) was used assess changes s...

This randomized controlled trial compared the use of an intensive and conventional insulin protocol on clinical outcomes in patients with severe sepsis and septic shock, in the first 72 hours. It was conducted at a university hospital in the city of São Paulo. Patients (n=46) were allocated into two groups: intensive glycemic (blood glucose between 80-110mg/dl) and conventional (180-220mg/dl). ...

Editor—I continue to be confounded by the use of target-controlled propofol infusion (TCI) dosing paradigm as an accepted basis for presenting the scientific study in anaesthesia journals without specific documentation of instantaneous and total dose infusion rates, in conjunction with body weight and duration of infusion at the study point. Although TCI may be utilitarian in the clinical admin...

BACKGROUND The combination of propofol-remifentanil for procedural deep sedation in spontaneously breathing patients is characterized by the frequent incidence of side effects, especially respiratory depression. These side effects may be due to either the drug combination or the drug delivery technique. Target-controlled infusion (TCI) might optimize drug delivery. In this prospective, randomiz...

BACKGROUND It has been suggested that diabetes mellitus type 2 amplifies the endocrine-metabolic stress response to surgery, and patients become more catabolic during the postoperative period. The aim of this study, conducted in patients with diabetes mellitus type 2 scheduled to undergo elective colorectal surgery, was to determine whether the anabolic effects of intravenous amino acids are mo...