Supplementation of mesenchymal stem cells (MSCs) during hematopoietic stem cell (HSC) transplantation alleviates complications such as graft-versus-host disease, leading to a speedy recovery of hematopoiesis. To meet this clinical demand, a fast MSC expansion method is required. In the present study, we examined the feasibility of using a rotary bioreactor system to expand MSCs from isolated bo...

Anaerobic biological wastewater treatment has numerous advantages over conventional aerobic processes; anaerobic biotechnologies, however, still have a reputation for low-quality effluents and operational instabilities. In this study, anaerobic bioreactors were augmented with an oxygen-transferring membrane to improve treatment performance. Two anaerobic bioreactors were fed a synthetic high-st...

There is growing interest in the chemical engineering community in the development of environmentally friendly products such as biopolymers. Poly-βhydroxybutyrate (PHB) is an important biopolymer whose commercial application is still limited due to the high costs associated with its production. This paper examines a continuous bioreactor proposed for the production of PHB. The influence of mino...

We consider a control problem for a single bioreaction occuring in a continuous and well mixed bioreactor, assuming that the bioreaction’s kinetics is not represented by a validated model. We develop a nonlinear controller and prove the global asymptotic stability of the closed loop system towards the equilibrium corresponding to the set point. Since this control law needs the knowledge of some...

. Abstrad This paper proposes a new Kalman Filter Recurrent Neural Network (I0 topology and a recursive Levenberg-Marquardt (L-M) second order learning algorithm capable to estimate parameters and states of highly nonlinear bioprocess in a noisy environment The proposed KFRNN identifier, learned by the Backpropagation and L-M learning algorithm, was incorporated in a direct adaptive neural cont...

The optimization of the operation of biological reactors is an interesting non-linear problem whose solution o!ers potential economic bene"t. We apply a peak seeking method to approach the maximum biomass production rate in a continuous stirred tank bioreactor. Two models, Monod and Haldane, are investigated and it is shown by simulation that the peak seeking scheme achieves optimization for bo...

Polyurethane-immobilized Flavobacterium cells (ATCC 39723) degraded pentachlorophenol (PCP) at initial concentrations as high as 300 mg liter-1. The reversible binding of PCP to the polyurethane was shown to be important in the protection of the cells from inhibition of PCP degradation. The degradation activity of the bacteria was monitored for 150 days in semicontinuous batch reactors. The deg...