Background: Comprehensive genomic profiling (CGP) enables physicians to recommend advanced cancer treatments at the individual level by identifying patients that are likely and unlikely benefit from targeted therapy or immunotherapy (IO). We assessed utility of CGP-based testing for biomarkers associated with approved therapies, therapies in precision medicine basket clinical trials (CT) across...

The present study was conducted with the aim being to investigate the effect γ-aminobutyric acid type B (GABAB) receptor activation have on spatial cognitive function and hippocampal neurones found in the rat models of type 2 diabetes mellitus (T2DM). T2DM rat models were then established, randomized, and subsequently assigned into normal control (NC), T2DM, T2DM + chemical grade propylene (CGP...

OBJECTIVE The primary objective was to evaluate the effectiveness of a Web-based program, Monitor-Rx, in identifying older adults at risk for drug-related geriatric syndromes or inappropriate medicines. DESIGN This prospective pilot study compared medication related risks generated by the Web-based program with those identified by a certified geriatric pharmacist (CGP). SETTING Wisconsin-ba...

UNLABELLED Cardiac sympathetic function plays an important role in the regulation of left ventricular (LV) function and the pathophysiology of LV dysfunction. (11)C-CGP-12177 ((11)C-CGP) has been used to assess myocardial beta-adrenergic receptor (beta-AR) density in vivo using PET. The aim of this study is to measure myocardial beta-AR density in patients with nonischemic cardiomyopathy and to...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 the radicular groove is a developmental anomaly that predisposes the tooth to periodontal break-down. sometimes the situation becomes more complicated by pulp necrosis and development of a combined endodontic-periodontal lesion which is a diagnostic and treatment challenge for the clinician. this report presents the succes...

In this study I attempted to assess, in rats, the role of AT1 and AT2 angiotensin receptor subtypes in the phenomenon of improved learning and memory after an intracerebroventricular (icv) injection of angiotensin II (Ang II) and Ang II (3-7). Selective AT1 (losartan, 1 mg) or AT2 (CGP 42112 A, 2 micrograms) receptor antagonist was dissolved in 2 microliters of saline and given to the left cere...

Neuronal activity in posterior cingulate cortex (CGp) is modulated by visual stimulation, saccades, and eye position, suggesting a role for this area in visuospatial transformations. The goal of this study was to determine whether neuronal responses in CGp are anchored to the eyes, head, or outside the body (allocentrically). To discriminate retinocentric from nonretinocentric spatial referenci...

The ras oncogene-encoded p21 protein is known to induce cell maturation of Xenopus laevis oocytes and malignant transformation of NIH 3T3 mouse fibroblasts. The pathways involved in oocytes and NIH 3T3 cells appear to be similar to one another. For example, in both cases, the ras p21-induced cellular events involve increased intracellular levels of the second messengers diacylglycerol and inosi...

Abnormal regulation of the renin angiotensin system such as enhanced renal AT1R function and reduced ACE2 activity contributes to obesity-related hypertension. Here, we tested whether long-term AT2R activation affects renal function in obesity using lean and obese Zucker rats treated with the AT2R agonist CGP42112A for 2 weeks. This caused blood pressure to decrease by 13 mm Hg, which was assoc...