The most frequent epigenetic alterations in Wilms tumor (WT) occur at WT2, assigned to 11p15. WT2 consists of two domains: telomeric domain 1 (DMRH19) that contains the IGF2 gene and an imprinted maternally expressed transcript (H19) and centromeric domain 2 (KvDMR) that contains the genes KCNQ1, KCNQ1OT1 and CDKN1C. In this work, we used pyrosequencing and MS-MLPA to compare the methylation pa...

A quantitative structure activity relationship analysis was applied to a library of 51 benzylacetamide derivatives with anticonvulsant activity. The molecular structures of 51 compounds were optimized with the Semiempirical Method PM6 (Parametric Method-6) included in the MOPAC2009 software. The optimized structures of all the examined compounds were represented by 1497 DRAGON-type descriptors....

Traditional and complementary medicine (T&CM) plays an integral role in providing health care worldwide. It is based on sound fundamental principles and centuries of practices. This study compared traditional Indian medicine (TIM) and traditional Korean medicine (TKM) basing on data obtained from peer reviewed articles, respective government institutional reports and World Health Organization r...

This Article defends racial integration as a central goal of race-based affirmative action. Racial integration of mainstream institutions is necessary both to dismantle the current barriers to opportunity suffered by disadvantaged racial groups, and to create a democratic civil society. Integration, conceived as a forward-looking remedy for de facto racial segregation and discrimination, makes ...

AIM To examine constitutional alterations of CDKN2A/p16INK4A locus as a potential indicator of melanoma predisposition among the first-degree relatives of patients with malignant melanoma. METHOD The study included eight families with a single member affected with melanoma. Members of the families were screened for allelic cosegregation with 9p21 region polymorphic markers IFNA, D9S126, and D...

Book details S. Jasanoff (ed.), Reframing Rights: Bioconstitutionalism in the Genetic Age, Cambridge MA: MIT Press, 2011: 310 pages, ISBN: 978-0-262-51627-3 Shelia Jasanoff ’s new edited volume on bioconstitutionalism provides an innovative and conceptually coherent analysis of the dynamic relationship between new technologies and constitutional frameworks. It is a most welcome introduction to ...

Background: The existence of moral challenges resulting from political, social and economic crises is an inevitable issue of any society and government. Challenges are not urgent, they gradually turn into crises, and can ultimately pose a serious threat to the sovereignty. The Qajar government was in such a situation, especially after the Constitutional Revolution. Political crises and its inte...

  Background: The aim of this review article is to analyze the results of high tibial osteotomy compared to unicompartmental knee arthroplasty in patients with unicompartmental knee osteoarthritis.   Methods: The search engine used was PubMed. The keywords were: "high tibial osteotomy versus unicompartmental knee arthroplasty". Twenty-one articles were found on 28 February 2015, but only eighte...

Steve Sexton......................................9 Proposition 37 is an initiative peti­ tion that, if adopted by Califor­ nia voters in November 2012, will impose mandatory labeling on a broad range of raw and processed foods. Specifically, proposed Section 110809 mandates that a food that “is or may have been entirely or partially produced with genetic engineering” state that fact through sp...