Conjugated linoleic acid (CLA) is formed from linoleic acid (LA; cis-9,cis-12-18:2) by intestinal bacteria. Different CLA isomers have different implications for human health. The aim of this study was to investigate LA metabolism and the CLA isomers formed in two individuals (V1 and V2) with different faecal metabolic characteristics, and to compare fatty acid metabolism with the microbial com...

Treatment of laboratory animals with a 50:50 mixture of c9,t11 and t10,c12 conjugated linoleic acid (CLA) results in fat loss and, to a smaller degree, fat-free mass (FFM) gain. In a previous meta-analysis, we found that CLA produced a fat loss, but that humans were not as responsive as mice. We performed a similar meta-analysis in the same 18 studies to test whether CLA increased FFM. Only pla...

Conjugated linoleic acid (CLA), a derivative of a fatty acid linoleic acid (LA), has been reported to decrease tumorigenesis in animals. CLA is unique because unlike most antioxidants which are components of plant products, it is present in food from animal sources such as dairy foods and meats. CLA concentrations in dairy products typically range from 2.9 to 8.92 mg/g fat of which the 9-cis, 1...

Fatty acids containing trans unsaturated double bonds occur in nature, but the most common dietary source are “man-treated” fats. Because of the possible link between trans-fatty acids consumption and human disease-mainly cardiovascular disease and cancer, the health effects of trans-FA have been studied for over the last fifty years. Trans fatty acids are unsaturated fatty acids with at least ...

The bovine stearoyl-CoA desaturase (Scd) gene plays an important role in the bovine mammary gland where substrates such as stearic and vaccenic acids are converted to oleic acid and conjugated linoleic acid (CLA), respectively. Up to 90% of the CLA in bovine milk is formed due to the action of this enzyme in the mammary gland. The areas of the bovine promoter of importance in regulating this ke...

The objective of this work was to evaluate the conjugated linoleic acid content (CLA), the fatty acid profile, and the chemical composition of the Longissimus muscle (LM) of steers and bulls finished in pasture systems. Fourteen 1/2 Nelore×1/2 Aberdeen Angus cattle were studied. The animals were slaughtered at approximately 20 months of age, with an approximate final liveweight of 480kg. Moistu...

Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. CLA has been reported to be able to reduce body fat. In this study, we investigated the antidiabetic effect of fermented milk (FM) containing CLA on type II diabetes db/db mice. Mice were treated with 0.2% low FM, 0.6% high FM, or Glimepiride (GLM) for 6 wk. Our resu...

Conjugated linoleic acids (CLA) are a family of isomers of linoleic acid. CLA increases growth arrest and apoptosis of human colorectal cancer cells through an isomer-specific manner. ATF3 belongs to the ATF/CREB family of transcription factors and is associated with apoptosis in colorectal cancer. The present study was performed to investigate the molecular mechanism by which t10, c12-CLA stim...