OBJECTIVE To evaluate changes in cognitive and academic functioning following cardiac surgery in children with congenital heart disease. DESIGN A prospective cross sectional study in which patients were assessed immediately before treatment and 12 months later. PATIENTS Three groups of children aged 3.5-17 years: a group with congenital heart disease awaiting surgery, another awaiting bone ...

Congenital heart defects comprise the most common form of major birth defects, affecting 0.7% of all newborn infants. Jacobsen syndrome (11q-) is a rare chromosomal disorder caused by deletions in distal 11q. We have previously determined that a wide spectrum of the most common congenital heart defects occur in 11q-, including an unprecedented high frequency of hypoplastic left heart syndrome (...

BACKGROUND Echocardiography remains a key noninvasive cardiac investigative tool in the management of patients, especially in a developing economy like Nigeria. In this study, we investigated the indications for transthoracic echocardiography and spectrum of cardiac disease found in patients referred to our cardiac unit for echocardiography. METHODS A prospective two-dimensional, pulsed, cont...

Cardiac disease is the leading medical cause of material death during pregnancy in the United Kingdom.1 Due to recent advances in cardiac surgery and congenital heart disease, the butter is now the most common subtrate of heart disease in pregnancy in the western world.2 The combination of cardiac disease and pregnancy carry mortality and morbidity risks such as heart failure, thromboembolism, ...

As surgical and catheter interventions advance, patients with congenital heart disease are now offered alternative treatment options that cater to their individual needs. Furthermore, collaboration between interventional cardiologists and cardiac surgeons have led to the development of hybrid procedures, using the best techniques of each respective field to treat these complex cardiac entities ...

Holt-Oram syndrome is clinically characterized by morphological abnormalities of the upper limbs and congenital cardiac defects. Although the disease is congenital, the diagnosis may only be made later in life. It is a rare autosomal dominant disorder, caused by a mutation in the TBX5 gene located on chromosome 12, but sporadic cases have also been reported. We describe the case of a 75-year-ol...

migration of cardiac neural crest cells into the pharyngeal arches and the pharyngeal and splanchnic mesoderm contributes to the development of the cardiac outflow tract. the adrenal cortex is derived from the splanchnic mesoderm. neuroblastoma is more prevalent in patients with congenital heart disease than in the general population, because both originate from embryonal neural crest-derived c...

A complication is an event or occurrence that is associated with a disease or a healthcare intervention, is a departure from the desired course of events, and may cause, or be associated with, suboptimal outcome. A complication does not necessarily represent a breech in the standard of care that constitutes medical negligence or medical malpractice. An operative or procedural complication is an...