RPE65 is a retinoid isomerase required for the production of 11-cis-retinal, the chromophore of both cone and rod visual pigments. We recently established an R91W knock-in mouse strain as homologous animal model for patients afflicted by this mutation in RPE65. These mice have impaired vision and can only synthesize minute amounts of 11-cis-retinal. Here, we investigated the consequences of thi...

This talk presents results of our study of heavy-to-light transition form factors extracted with the help of light-cone sum rules. We employ a model with scalar particles interacting via massless-boson exchange and study the heavy-to-light correlator, relevant for the extraction of the transition form factor. We calculate this correlator in two different ways: by making use of the Bethe–Salpete...

Recently, Cho et al. [Y. J. Cho, R. Saadati, S. H. Wang, Common xed point theorems on generalized distance in ordered cone metric spaces, Comput. Math. Appl. 61 (2011) 1254-1260] dened the concept of the c-distance in a cone metric space and proved some xed point theorems on c-distance. In this paper, we prove some new xed point and common xed point theorems by using the distance in ordered con...

ultimate limits of an open pit, which define its size and shape at the end of the mine’s life, is the pit with the highest profit value. a number of algorithms such as floating or moving cone method, floating cone method ii and the corrected forms of this method, the korobov algorithm and the corrected form of this method, dynamic programming and the lerchs and grossmann algorithm based on grap...

We introduce a new method to include condensates in the light-cone Hamilto-nian. By using a Gaussian approximation to the ordinary vacuum in a theory close to the light front, we derive an effective Hamiltonian on the light cone, which has new terms reflecting the nontriviality of the vacuum. We demonstrate our method for scalar φ 4-theory and the massive Schwinger model.

previous evidence has shown that the number of l and m cones in retina varies significantly between subjects. however, it is not clear how the variation of l/m ratio changes the behavioral performance of the subject. a model of transformation of data from retina to visual cortex for evaluation of various l/m cones ratios is presented. while l/m cone ratios close to 1 brings the best performance...

Leber congenital amaurosis (LCA), a severe autosomal recessive childhood blindness, is caused by mutations in at least 15 genes. The most common molecular form is a ciliopathy due to NPHP6 (CEP290) mutations and subjects have profound loss of vision. A similarly severe phenotype occurs in the related ciliopathy NPHP5 (IQCB1)-LCA. Recent success of retinal gene therapy in one form of LCA prompte...

The biosorption performance of raw cone shell of Calabrian pine for C.I. Basic Red 46 as a model azo dye from aqueous system was optimized using Taguchi experimental design methodology. L9 (3(3)) orthogonal array was used to optimize the dye biosorption by the pine cone shell. The selected factors and their levels were biosorbent particle size, dye concentration, and contact time. The predicted...