The mode of furfural accumulation was determined in aseptically filled containers of single-strength orange juice and concentrates during storage at six different temperatures. Results showed that furfural accumulated in orange juice more rapidly than in concentrates of 34,44, and 58 OBrix. There was 4 times the amount of furfural in orange juice (12 "Brix) than in concentrate (58 "Brix) stored...

Repeated exposure to foreign human leukocyte antigens (HLA) present on both platelets and leukocytes often results in refractoriness to transfusions of platelet concentrates. Evidence now exists which suggests that the leukocytes are more immunogenic and that their removal from blood products may delay or prevent the development of refractoriness. In this study, the ability of three blood filte...

Recombinant factor VIII and factor IX concentrates, human-plasma–derived albumin, and samples from previously untreated patients with hemophilia were examined for the presence of TT virus (TTV) by using polymerase chain reaction testing. Blood samples from the patients were obtained prospectively before and every 3 to 6 months after therapy was begun. TTV was detected in 23.5% of the recombinan...

The main feature of this new approach to platelet freezing is a controlled rate of addition and postthaw removal of 5#{176}/odimethylsulfoxide (DMSO). When DMSO was removed from fresh nonfrozen platelet concentrates before transfusion, no adverse effect on posttransfusion survival was observed. The 51Cr recovery of autologous fresh platelet concentrates in vivo was 65#{176}/o ± 5#{176}/o, while...

Recombinant factor VIII and factor IX concentrates, human-plasma-derived albumin, and samples from previously untreated patients with hemophilia were examined for the presence of TT virus (TTV) by using polymerase chain reaction testing. Blood samples from the patients were obtained prospectively before and every 3 to 6 months after therapy was begun. TTV was detected in 23.5% of the recombinan...

In previous studies, we have shown that some, but not all low-, intermediate-, and high-purity factor VIII concentrates inhibit interleukin-2 (IL-2) secretion from phytohemagglutinin (PHA)-stimulated T lymphocytes. We now present evidence that this inhibitory action of concentrates is, at least in part, due to contamination with transforming growth factor-beta (TGF-beta). Originally identified ...

There is an ongoing debate whether platelet concentrates (PCs) prepared from either whole-blood donations or by plateletpheresis are superior. Usage of these two product types varies greatly between countries and individual institutions. Some use mainly apheresis PCs; others prefer pooled PCs which are produced from whole-blood donations. This review summarizes the existing information on these...

Background Incidence and mortality from traumatic intra-cranial haemorrhage (ICH) is increased in patients on warfarin [1]. Prothrombin Complex Concentrates (PCC) rapidly reverse warfarin anti-coagulation and have been shown to reduce haematoma expansion and mortality in warfarinised patients sustaining ICH [2]. We aimed to determine the feasibility of pre-hospital use of PCCs by physicians and...

My dissertation concentrates on several aspects of supply chain management and economic valuation of real options in the natural gas and liquefied natural gas (LNG) industry, including gas pipeline transportation, ocean LNG shipping logistics, and downstream storage. Chapter 1 briefly introduces the natural gas and LNG industries, and the topics studied in this thesis. Chapter 2 studies how to ...