We synthesized and evaluated three novel series of substituted benzophenones for their allosteric modulation the human K v 11.1 (hERG) channel. compared effects with reference compound LUF7346 previously shown to shorten action potential cardiomyocytes derived from stem cells. Most compounds behaved as negative modulators (NAMs) [ 3 H]dofetilide binding Compound 9i was most potent amongst all l...

We propose a coding scheme that achieves the capacity of the compound MIMO channel with algebraic lattices. Our lattice construction exploits the multiplicative structure of number fields and their group of units to absorb ill-conditioned channel realizations. To shape the constellation, a discrete Gaussian distribution over the lattice points is applied. These techniques, along with algebraic ...

Relative 235 U(n,γ) and (n,f) cross sections from 235 U(d,pγ) and (d,pf) The internal surrogate ratio method allows for the determination of an unknown cross section, such as (n,γ), relative to a better-known cross section, such as (n,f), by measuring the relative exit-channel probabilities of a surrogate reaction that proceeds through the same compound nucleus. The validity of the internal sur...

Ion transport from one aqueous (W1) to another (W2) across bilayer lipid membranes (BLM) containing gramicidin A (GA) was investigated by recording current fluctuations, when various alkali metal chlorides and potassium salts were used as supporting electrolytes. The magnitude of the single-channel current at a given membrane potential depended on not only the cationic species, but also on the ...

We determine the optimal rates of universal quantum codes for entanglement transmission and generation under channel uncertainty. In the simplest scenario the sender and receiver are provided merely with the information that the channel they use belongs to a given set of channels, so that they are forced to use quantum codes that are reliable for the whole set of channels. This is precisely the...

The paper presents a new mathematical model of TCP (Transmission Control Protocol) link functioning in heterogeneous (wired/wireless) channel. It represents controllable, partially observable stochastic dynamic system. system state describes the status modeled and expresses it via an unobservable controllable MJP (Markov jump process) with finite-state space. Observations are formed by low-freq...

We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss considerations regarding the choice of caging molecule, synthesis and the potential uses for caged...

In this paper, we propose a robust quantizer design for image coding. Because the bits representing the reconstruction levels are transmitted directly to the channel, the proposed quantizer can be viewed as a compound of a quantizer, a VLC coder, and a channel coder. The conventional combined source/channel design produces a source coder designed for a channel with a specific channel noise. Our...

A tetra-ortho-chloro substituted azobenzene unit was incorporated into a photoswitchable tethered ligand for ionotropic glutamate receptors. This compound confers the modified protein with the unusual optical responses of the substituted azo scaffold permitting channel opening with yellow and red light and channel closing with blue light.

We derive inner and outer bounds on the capacity region of a class of compound interference channels and quantify the gap between these bounds. From this we derive the capacity region of the compound version of El Gamal and Costa’s deterministic interference channel, and characterize to within 3 bits the capacity region of scalar compound Gaussian interference channels. Our main contributions i...