So far, only a few of the interactions between the ≈ 30 nucleoporins comprising the modular structure of the nuclear pore complex have been defined at atomic resolution. Here we report the crystal structure, at 2.6 Å resolution, of a heterotrimeric complex, composed of fragments of three cytoplasmically oriented nucleoporins of yeast: Nup82, Nup116, and Nup159. Our data show that the Nup82 frag...

The aM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. The N-terminal region has been predicted to fold into a b-propeller domain composed of seven b-sheets each about 60 amino acid residues long, with the I-domain inserted between b-sheets 2 and 3. The structure of the C-terminal region is unknown. We have used monoclonal antibodies (mAbs) as probes to...

Keap1 is a substrate adaptor of a Cullin 3-based E3 ubiquitin ligase complex that recognizes Nrf2, and also acts as a cellular sensor for xenobiotics and oxidative stresses. Nrf2 is a transcriptional factor regulating the expression of cytoprotective enzyme genes in response to such stresses. Under unstressed conditions Keap1 binds Nrf2 and results in rapid degradation of Nrf2 through the prote...

In AE Aqr, magnetic elds transfer energy and angular momentum from a rapidly spinning white dwarf to material in the gas stream from the companion star, with the eeect of spinning down the white dwarf while inging the gas stream material out of the binary system. This magnetic propeller produces a host of observable signatures, chief among which are broad single-peaked aring emission lines with...

Abstract During the ground operation of aircraft, the interaction between the propulsor-induced flow field and the ground may lead to the generation of ground vortices. Utilizing numerical approaches, the source of vorticity entering ground vortices is investigated. The results show that the production of wall-parallel components of vorticity has a strong contribution from the wall-parallel com...

The Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction (PROPELLER) method for magnetic resonance imaging data acquisition and reconstruction has the highly desirable property of being able to correct for motion during the scan, making it especially useful for imaging pediatric or uncooperative patients and diffusion imaging. This method nominally supports a circular fi...

The emergence of resistance to artemisinin derivatives in Southeast Asia, manifested as delayed clearance of Plasmodium falciparum following treatment with artemisinins, is a major concern. Recently, the artemisinin resistance phenotype was attributed to mutations in portions of a P. falciparum gene (PF3D7_1343700) encoding kelch (K13) propeller domains, providing a molecular marker to monitor ...

Recommended Citation Chase, Nathan. "Simulations of the DARPA Suboff submarine including self-propulsion with the E1619 propeller. ii ACKNOWLEDGEMENTS I would like to thank my advisor, Dr. Pablo Carrica. His guidance and encouragement throughout my graduate career has been instrumental. I would also like to thank my other committee members, Dr. Fred Stern and Dr. Ching-Long Lin, for taking time...

BACKGROUND Post-burn axillary and elbow scar contracture is a challenging problem to the reconstructive surgeon owing to the wide range of abduction and extension that should be achieved, respectively, while treating either of the joint. The aim of this paper is to highlight the use of subcutaneous pedicle propeller flap for the management of post-burn axillary and elbow contractures. METHODO...