background: thalassemia is a series of hemoglobinopathies in which the production of perfect hemoglobin is completely or partially suppressed. using injectable iron chelators have been dominating treatment for the iron overload caused by recurrent blood transfusions in thalassemic patients, however, a new oral iron chelating drug (exjade) have been recently introduced and might be cost effectiv...

Compliance is usually defined as "the extent to which the patient's behaviour in terms of taking medications, following diets, or changing life style, coincides with the clinical prescription" [1]. This is a non-operative description which only refers to the patient, saying nothing about who gives and the quality of what is given, is often used to put the blame on the patient and to reassure th...

BACKGROUND Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin. OBJECTIVES To compare the efficacy of a cosmetic moisturizer regimen vs. a prescription regimen ...

BACKGROUND Hypertension is a leading cause of death worldwide, and a major public health problem in Canada. Despite treatment guidelines and availability of therapies for blood pressure (BP) management, treatment of hypertension remains sub-optimal. OBJECTIVES The objectives of this trial are to observe BP reduction, compliance and regimen changes 3 months after initiation of valsartan alone ...

furazolidone (fzd), a nitrofuran derivative, is an antibacterial agent in use by the medical and veterinary fields. the chinese have utilized fzd to relieve stomach pain, 5 years before the discovery of helicobacter pylori. this drug is currently a part of helicobacter pylori's eradication regimen. however, some carcinogenic and toxic adverse effects associated with fzd have been observed in an...

The effectiveness of current treatments for osteoporosis is limited by poor patient compliance. However, a favorable dosing regimen of zoledronic acid (ZA) has the potential to improve patient compliance and thus clinical outcomes. The author conducted a retrospective analysis to examine adherence to and the antiosteoporotic effects of a once-yearly infusion of 5 mg of ZA in Taiwanese patients ...

OBJECTIVE The aim of the study is to provide guidance regarding the meaning and use of the terms "compliance" and "persistence" as they relate to the study of medication use. METHODS A literature review and debate on appropriate terminology and definitions were carried out. RESULTS Medication compliance and medication persistence are two different constructs. Medication compliance (synonym:...

OBJECTIVE Early use of insulin after diagnosis of type 2 diabetes is met with resistance because of associated weight gain, hypoglycemia, and fear of decreased compliance and quality of life (QoL). RESEARCH DESIGN AND METHODS In treatment-naive patients with newly diagnosed type 2 diabetes, insulin and metformin were initiated for a 3-month lead-in period, then patients were randomly assigned...