Perfusion of 5 microM kainate through microdialysis probes induced >2-fold elevation of extracellular uridine and adenosine concentrations in the hippocampus and in the thalamus of anaesthetized rats. Administration of uridine via this route produced an estimated uridine concentration of 50-100 microM around the electrode surface. This markedly decreased the average firing rate of neurones in t...
