Chronic restraint stress (CRS) has detrimental effects on cognitive function. Hydrogen sulfide (H2S), as a neuromodulator, regulates learning and memory. Hippocampus is a key structure in learning and memory. Sirt1 (silence signal regulating factor 1) plays an important role in modulating cognitive function. Therefore, our present work was to investigate whether H2S meliorates CRS-induced damag...

Aim: Chronic rhinosinusitis (CRS) is characterized by persistent inflammation of the nasal and paranasal sinus mucosa. The pathogenesis of chronic sinusitis is not yet clearly understood. Recently, mean platelet volume (MPV) has been known as a simple inflammatory marker in inflammatory diseases. The aim of this study was to investigate the levels of hematological parameters such as red blood c...

BACKGROUND Chronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. We previously reported that the prevalence of CRS was about 8 % in China. Here, we aim to investigate the occupational and environmental risk factors associated with CRS. METHODS Data were collected from seven Chinese cities: Urumqi, Changchun, Bei...

The chronic inflammatory nature of chronic rhinosinusitis (CRS) makes it a morbid condition for individuals with the disease and one whose pathogenesis is poorly understood. To date, proteomic approaches have been applied successfully in a handful of CRS studies. In this study we use a multifaceted approach, including proteomics (iTRAQ labeling) and microbiome (bacterial 16S rRNA gene sequencin...

where A is a matrix and x, b are vectors and n is the realization of random noise. We analyze the solution x̂ = A−1b which is completely dominated by noise. A useful solution can only be obtained by using additional information about the true solution x∗. The resulting solution x̂ is called the regularized solution of the inverse problem. Two popular regularization techniques, Tikhonovand total v...

INTRODUCTION Assessment of respiratory system compliance (Crs) can be used for individual optimization of positive end-expiratory pressure (PEEP). However, in patients with spontaneous breathing activity, the conventional methods for Crs measurement are inaccurate because of the variable muscular pressure of the patient. We hypothesized that a PEEP wave maneuver, analyzed with electrical impeda...

171 Augmentation of cxcl10 Expression in Nasal Fibroblasts Derived from Patients With Recalcitrant Chronic Rhinosinusitis Associated With Bronchial Asthma Mamoru Yoshikawa, MD, Tsuyoshi Yoshimura, MD, Daiya Asaka, MD, Naoko Okada, PhD, Hirohisa Saito, MD, PhD, and Hiroshi Moriyama, MD. Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan; National Research Instit...

As important informatics interventions, clinical reminders (CRs) translate emerging knowledge into accessible advice at the point-of-care. In a timely fashion, CRs prompt clinicians to take specific actions that can improve or optimize patient care. To ensure that CRs achieve their desired impact, systems must deliver CRs to the clinicians most likely to act on them. Sadly, CRs many times pass ...

BACKGROUND The nose and the bronchi belong, in anatomical and physiopathological terms, to the concept of united airways. Associations between upper and lower airways diseases have been demonstrated in allergic rhinitis and asthma, nasal polyposis (NP) and asthma, chronic rhinosinusitis (CRS) and chronic obstructive pulmonary disease, and more recently CRS/NP and bronchiectasis (BQ). OBJECTIV...

It is well known that chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease. In fact, studies have shown that cardiovascular event rates and allcause mortality increase as a function of CKD as determined by decrease in estimated glomerular filtration rate and presence of microalbuminuria. In recent years, the term cardiorenal syndrome (CRS) has been proposed t...