Protein kinase-directed cancer therapies yield impressive initial clinical responses, but the benefits are typically transient. Enhancing the durability of clinical response is dependent upon patient selection, using drugs with more effective pharmacology, anticipating mechanisms of drug resistance, and applying concerted drug combinations. Achieving these tenets requires an understanding of th...

23 The effects of Deep Brain Stimulation (DBS) on balance in people with Parkinson’s Disease 24 (PD) are not well established. This study examined whether DBS randomized to the 25 subthalamic nucleus (STN, n=11) or globus pallidus interna (GPi, n=10) improved 26 compensatory stepping to recover balance following a perturbation. The standing surface 27 translated backwards, forcing subjects to t...

The effects of deep brain stimulation (DBS) on balance in people with Parkinson's disease (PD) are not well established. This study examined whether DBS randomized to the subthalamic nucleus (STN; n = 11) or globus pallidus interna (GPi; n = 10) improved compensatory stepping to recover balance after a perturbation. The standing surface translated backward, forcing subjects to take compensatory...

humidity, temperature, and wind could account for variation in the spectral characteristics of Dupont’s lark song (as larks are aerial singers). However, no prior hypothesis has suggested that these could cause shifts in song-/calltype abundance, the focus of our paper, and such abiotic factors are even less likely to covary with habitat fragmentation. We are aware of the studies on natural voc...

BACKGROUND Uncertainty and predictability have remained at the center of the study of human attention. Yet, studies have only examined whether response times (RT) or fixations were longer or shorter under levels of stimulus uncertainty. To date, no study has examined patterns of stimuli and responses through a unifying framework of uncertainty. METHODOLOGY/PRINCIPAL FINDINGS We asked 29 colle...

To identify key regulators of subminimum inhibitory concentration (sub-MIC) antibiotic response in the Pasteurella multocida proteome, we applied systems approaches. Using 2D-LC-ESI-MS(2), we achieved 53% proteome coverage. To study the differential protein expression in response to sub-MIC antibiotics in the context of protein interaction networks, we inferred P. multocida Pm70 protein interac...

Past studies have shown that speakers spontaneously adjust their speech acoustics in response to their auditory feedback perturbed in real time. In the case of formant perturbation, the majority of studies have examined speaker's compensatory production using the English vowel /ɛ/ as in the word "head." Consistent behavioral observations have been reported, and there is lively discussion as to ...

Although laboratory and observational studies suggest that many animals are capable of compensatory growth after periods of food shortage, few field experiments have demonstrated structural growth compensation in the wild. Here, we addressed the hypotheses that (i) food restriction can induce structural compensatory growth in free-living animals, (ii) that compensation is proportional to the le...

Hsia, Connie C. W. Signals and mechanisms of compensatory lung growth. J Appl Physiol 97: 1992–1998, 2004; doi:10.1152/japplphysiol.00530.2004.— Growth of the lung involves unique structure-function interactions not seen in solid organs. Mechanical feedback between the lung and thorax constitutes a major signal that sustains developmental as well as compensatory lung growth. After the loss of l...