Biofilm is the dominant form of skin microbiota organization that provides adhesion and preservation microorganisms in micro-environment. It necessary to ensure epidermal barrier function local immunomodulation. Staphylococcus aureus becomes major colonizer lesions case atopic dermatitis exacerbation, it also can biofilms. S. growth biofilm formation due other microbial commensals on patients w...

Abstract Introduction The DUOX2 intestinal epithelial NADPH oxidase is upregulated in Crohn’s Disease (CD), and mutations are associated with increased CD risk. Oxidative stress loss of mitochondrial function disrupt the barrier promoting inflammatory responses to commensals. relative impact microbial products this regard poorly understood. Hypothesis We hypothesized that genetic variation woul...

OBJECTIVE To investigate the bacteriological safety of preprepared endotracheal tubes in accident and emergency departments. METHODS Swabs were taken and cultured from luminal and exterior surfaces of every preprepared exposed endotracheal tube in a hospital resuscitation room. RESULTS Coagulase negative staphylococci (common skin commensals) were isolated from 50% of the tubes. No other ba...

Innate immune cells - and many other cells - express evolutionarily conserved, germline-encoded receptors that recognize seemingly pathogen-derived ligands (also termed pathogen-associated molecular patterns), thereby allowing the host to perceive infection. Although they were the first to be discovered, Toll-like receptors (TLRs) are not the only pattern recognition receptors. TLRs are unlikel...

Public transit systems are ideal for studying the urban microbiome and interindividual community transfer. In this study, we used 16S amplicon and shotgun metagenomic sequencing to profile microbial communities on multiple transit surfaces across train lines and stations in the Boston metropolitan transit system. The greatest determinant of microbial community structure was the transit surface ...

The genus Staphylococcus is virtually ubiquitous and, at the time of writing, represented by 37 species and numerous subspecies (http://www.bacterio.cict.fr/s/ staphylococcus.html). At least 12 of these staphylococcal species/subspecies are human commensals that can become opportunistic pathogens (Kloos et al., 1992). For example, Staphylococcus epidermidis (the most prevalent colonizer of the ...