We present wide-field imaging of the 2007 outburst of Comet 17P/Holmes obtained serendipitously by SuperWASP-North on 17 nights over a 42-night period beginning on the night (2007 October 22–23) immediately prior to the outburst. Photometry of 17P’s unresolved coma in SuperWASP data taken on the first night of the outburst is consistent with exponential brightening, suggesting that the rapid in...

Background The COMET Initiative recognises the expertise and crucial contribution of patients and carers in developing core outcome sets and research more generally. Core outcome sets need to include outcomes that are most relevant to patients and carers, and the best way to do this is to involve patients and carers in their development. COMET is developing resources to help patients and carers...

...........................................................................................................4 1. Short description of Rosetta as an instance of GUARDS...............................4 2. Modelling Approach for the Rosetta mission ................................................5 3. Level 0: Measures......................................................................................

The increasing request of chemical safety assessment demands for the validation of alternative methods to reduce the resort to animal experimentation. Methods that evaluate reproductive toxicity are among those requiring the largest use of animals. Presently, no validated in vitro alternative exists for the assessment of reproductive toxicity. Mammalian sperm are sensitive targets of DNA-reacti...

In the present study we analyzed and followed-up on the DNA damaging effects of microwave radiation of GEM radar equipment within microwave field of 10 μW/cm to 10 mW/cm in personnel occupationally exposed to frequency range of 1.5 GHz to 10.9 GHz. The single cell gel electrophoresis (SCGE)/comet assay as a tool for the biomonitoring of individuals accidentally, environmentally or occupationall...

Oxidized bases in DNA can be measured directly by high-performance liquid chromatography (HPLC). 7,8-Dihydro-8-oxo-guanine (8-OHgua), as the most abundant oxidation product, is often regarded as an indicator of oxidative stress. Estimates of endogenous 8-OHgua levels in human lymphocyte DNA are between 2 and 8 for every 10(5) unaltered bases--a high frequency in view of the potential mutagenici...

BACKGROUND In chronic liver diseases of different etiologies, including viral hepatitis, genotoxic effects of oxidative stress have been shown, both in clinical and in experimental conditions, suggesting that this mechanism may contribute to the evolution of the disease. AIM To evaluate DNA damage in the peripheral blood of untreated non-diabetic patients with chronic hepatitis C and control ...

BACKGROUND Nuclear texture analysis measures phenotypic changes in chromatin distribution within a cell nucleus, while the alkaline Comet assay is a sensitive method for measuring the extent of DNA breakage in individual cells. The authors aim to use both methods to provide information about the sensitivity of cells to ionizing radiation. METHODS The alkaline Comet assay was performed on six ...