نتایج جستجو برای: colorectal cancers
تعداد نتایج: 164124 فیلتر نتایج به سال:
Traditional Chinese medicine (TCM) has been increasingly employed in the last decades China for both preventing and treating a variety of cancers. 3-epi-bufotalin is an active ingredient TCM “Chanpi” with anti-tumor potential. However, effect mechanism on colorectal cancers were not well disclosed. The present study demonstrated that could reduce viability, trigger apoptosis, block cell cycle a...
OBJECTIVE Genome-wide association studies have identified a large number of single nucleotide polymorphisms (SNPs) associated with a wide array of cancer sites. Several of these variants demonstrate associations with multiple cancers, suggesting pleiotropic effects and shared biological mechanisms across some cancers. We hypothesised that SNPs previously associated with other cancers may additi...
BACKGROUND/AIM Matrilysin is one of the matrix metalloproteinases that has a critical role in tumour invasion, and is often expressed in gastrointestinal cancers. The aim of this study was to examine the role of matrilysin in metastasis of human colorectal cancers. PATIENTS (SUBJECTS)/METHODS: The relation between matrilysin expression and Dukes's type was investigated immunohistochemically in ...
We examined occupational and industrial differences in lung, gastric, and colorectal cancer risk among Japanese men of working age (25-64 years) using the 2010 Japanese national survey data for occupation and industry-specific death rates. Poisson regression models were used to estimate the age-adjusted incident rate ratios by lung, gastric, and colorectal cancers, with manufacturing used as th...
BACKGROUND High-degree microsatellite instability (MSI-H) is a feature of approximately 15% of sporadic colorectal cancers. Patients with MSI-H cancers have been reported to have a better prognosis than those with non-MSI-H cancers. The MSI-H subset is also characterised by a dense infiltrate of intra-epithelial lymphocytes and the hypothesis that the latter represents an efficacious immune res...
Genetic instability has emerged as an important hallmark of human neoplasia. Although most types of cancers exhibit genetic instability to some extent, in colorectal cancers genetic instability is a distinctive characteristic. Recent studies have shown that deregulation of genes involved in sister chromatid cohesion can result in chromosomal instability in colorectal cancers. Here, we show that...
GAEC1 (gene amplified in oesophageal cancer 1) is located at 7q22.1, first identified in oesophageal cancer. Initial work indicated that GAEC1 can act as an oncogene. Our pilot study found ∼80% of colorectal cancers showing amplification of GAEC1. In this research, we will study GAEC1 copy number in colon cancer cell lines and colorectal tissues, and its prognostic significance. Two human colon...
Cancers evolve as a result of the accelerated proliferation cancer cells in complicated, enriched, and active microenvironment. Tumor microenvironment (TME) components are master regulators any step development. The tumor is composed many cellular noncellular that contribute to evolution cells. Cancer-associated fibroblasts (CAFs) activated TME implicate progression metastasis dissemination thr...
Colorectal cancer is a major health concern since it highly diagnosed and the second cause of death among cancers. Thus, most suitable biomarkers for its diagnosis, prognosis, treatment have been studied to improve personalize prevention clinical management colorectal cancer. The emergence omic techniques has provided great opportunity better study CRC make personalized medicine feasible. In th...
Recently, an inducible microsomal human prostaglandin E synthase (mPGES) was identified. This enzyme converts the cyclooxygenase (COX) product prostaglandin (PG) H(2) to PGE(2), an eicosanoid that has been linked to carcinogenesis. Increased amounts of PGE(2) have been observed in many tumor types including colorectal adenomas and cancers. To further elucidate the mechanism responsible for incr...
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