Introduction: Multiple sclerosis (MS) is a disease of the immune system: it attacks the myelin around the axons and leaves them exposed. Destruction of myelin weakens the electrical conduction of ions and thus leads to a lack of communication in the nervous system.  Methods: In the present study, we constructed recombinant plasmid and then transformed to E. coli cell. The colonies containing...

Abstract Purpose:We conducted a phase II randomized non-comparative window of opportunity trial to evaluate the inhibition cellular proliferation and modulation immune microenvironment after treatment with Olaparib alone or in combination Cisplatin Durvalumab operable Head Neck Squamous Cell Carcinoma (HNSCC) patients. Patients Methods:Forty-one HNSCC patients were plus (Arm A), B), no C) D). T...

Recently, long noncoding RNAs (lncRNAs) have been reported to play important role in the pathogenesis of various cancers. However, functions RNF185-AS1 hepatocellular carcinoma (HCC) remain unknown. The expression HCC cells and tissues was measured by quantitative real-time polymerase chain reaction (qRT-PCR). effects on tumor cell proliferation, migration invasion were assessed Cell Counting K...

Colorectal cancer (CRC) is considered one of the leading types in world. CD133, as a stem cell marker, has pivotal role development drug resistance, migration, and stemness properties CRC cells. This study was designed to check combined effect CD133 siRNA Oxaliplatin on proliferation, apoptosis, cells HT-29 line. MTT assay performed define viability cells, it showed that combination could reduc...

Purpose: In September 2019, a rapidly spreading soft rot disease was observed in an Aloe vera cultivation Puttlam District, Sri Lanka causing rotting of leaves and whole plant death, within three to five days. Identification causal pathogen the main objective for effective management disease. The aim this study isolate molecular identification A. confirm its pathogenicity.Research Method: bacte...

Interleukin-11 (IL-11), a newly-identified cytokine produced by stromal cells, elevates platelet counts in neonatal rats in vivo and synergizes in vitro with IL-3 in supporting murine megakaryocyte colony formation and stimulating hematopoietic stem cells. Megakaryocytopoiesis is also enhanced by other colony-stimulating factors (CSFs), including IL-3, IL-6, and Steel factor (SLF). Dysregulatio...