The dynamic reorganization of the actin cytoskeleton is regulated by a number of actin binding proteins (ABPs). Four human colon adenocarcinoma cell lines - parental and three selected sublines, which differ in motility and metastatic potential, were used to investigate the expression level and subcellular localization of selected ABPs. Our interest was focused on cofilin and ezrin. These prote...

the most common metastatic sites for colorectal carcinomas include the liver, lungs, brain, bones and peritoneal surfaces. in this report, a case of sigmoid colon carcinoma presented with cervical lymphadenopathy was detected with the help of pet/ct. a 57 year-old male presented with a complaint of swelling on the left side of his neck. ultrasonographic examination of the neck revealed three hy...

Background: Necroptosis is a novel programmed cell death pathway proposed in 2005, which mainly activated by the tumor necrosis factor (TNF) family and mediates cellular disassembly via receptor interacting serine/threonine kinase 1 (RIPK1), 3 (RIPK3) mixed lineage domain like pseudokinase (MLKL). We tried to analyze relationship of necroptosis-related genes (NRGs) expression with colon adenoca...

AIM OF THE STUDY Evaluation of the relationships between increased expression of VEGF-C (vascular endothelial growth factor-C) and vessel density in the tumour-surrounding stroma, patient survival, and other conventional prognostic factors in patients with pT3-4 colon cancer. MATERIAL AND METHODS Expression of VEGF-C and vessel density were immunohistochemically assessed in 104 specimens of p...

Primula auriculata (Tootia) is one of the most important local medicinal plants in Hamedan district, Iran. To investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on HT-29 human colon Adenocarcinoma cells. Cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (MTT) a...

Aim Assessment of related genes to colon cancer to introduce crucial ones, was the aim of this research. Background Colon cancer is one of the invasive colorectal diseases. This disease is preventable and manageable if it be diagnosed in early stage. The aggressive tools for its detection imply more investigation for new molecular diagnostic methods. Methods Numbers of 300 genes from String...

Four major carcinoembryonic antigen-related glycopeptides (Mr 180,000, 160,000, 50,000, and 40,000) were detected in SW948 colon carcinoma cells and in colon adenocarcinoma tissue using a monoclonal antibody (C(4)20-32) generated by immunizing mice with SW1222 human colon carcinoma cells. Only the Mr 50,000 polypeptide was immunoprecipitated from normal colon mucosa by this antibody. Binding st...

Colorectal adenocarcinoma is the most common type of gastrointestinal cancer. Colon adenocarcinoma is a major health problem worldwide due to the high prevalence and mortality rates associated with the disease. The majority of colorectal carcinomas are adenocarcinomas, which originate from the epithelial cells of the colorectal mucosa. HT-29 cells, which originate from human colon adenocarcinom...

  Objective(s):Transforming growth factor-β(TGF-β) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent in different malignancies via TGF-β signaling. This work aims to show the effect of manipulation of TGF-β signaling on some miRNAs implicated in CRC. Materials and Methods: We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell li...

Aim: The identification of cellular pathways in colorectal tumor biology is essential for early diagnosis, treatment, and post-treatment follow-up. Osteopontin an extracellular matrix protein that has regulatory physiological functions roles apoptosis, proliferation, adhesion, invasion, metastasis. In this study, we aimed to determine the prognostic predictive value osteopontin colon adenocarci...