نتایج جستجو برای: collagen induced arthritis

تعداد نتایج: 1103161  

Journal: :Arthritis and rheumatism 2009
Hilke Brühl Josef Cihak Marianne Niedermeier Andrea Denzel Manuel Rodriguez Gomez Yvonne Talke Nicole Goebel Jirí Plachý Manfred Stangassinger Matthias Mack

OBJECTIVE Activation of basophils contributes to memory immune responses and results in exacerbation of collagen-induced arthritis (CIA). We undertook the present study to analyze the production and biologic effects of interleukin-3 (IL-3), a strong activator of basophils, in CIA. METHODS Arthritis was induced by immunization with type II collagen. Mice were treated with blocking monoclonal a...

2014
Yaakov A. Levine Frieda A. Koopman Michael Faltys April Caravaca Alison Bendele Ralph Zitnik Margriet J. Vervoordeldonk Paul Peter Tak

INTRODUCTION The inflammatory reflex is a physiological mechanism through which the nervous system maintains immunologic homeostasis by modulating innate and adaptive immunity. We postulated that the reflex might be harnessed therapeutically to reduce pathological levels of inflammation in rheumatoid arthritis by activating its prototypical efferent arm, termed the cholinergic anti-inflammatory...

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