Abstract Background Cranial radiation therapy for treating childhood malignancies in the central nervous system or accidental exposure may result neurological side effects surviving adults. As tissue homeostasis is maintained by stem cells, understanding effect of on neural cells will provide clues managing effects. Drosophila embryos were used as a model whose sensitivity to irradiation-induce...

Radiation therapy (RT) is a widely accepted treatment strategy for many central nervous system (CNS) pathologies. However, despite recognized therapeutic success, significant negative consequences are associated with cranial irradiation (CR), which manifests months to years post-RT. The pathophysiology and molecular alterations that culminate in the long-term detrimental effects of CR are poorl...