نتایج جستجو برای: cobra venom

تعداد نتایج: 10725  

2014
Aisha Munawar Maria Trusch Dessislava Georgieva Diana Hildebrand Marcel Kwiatkowski Henning Behnken Sönke Harder Raghuvir Arni Patrick Spencer Hartmut Schlüter Christian Betzel

Elapid snake venom is a highly valuable, but till now mainly unexplored, source of pharmacologically important peptides. We analyzed the peptide fractions with molecular masses up to 10 kDa of two elapid snake venoms-that of the African cobra, N. m. mossambica (genus Naja), and the Peninsula tiger snake, N. scutatus, from Kangaroo Island (genus Notechis). A combination of chromatographic method...

2014
Catherine A. Vulfius Igor E. Kasheverov Vladislav G. Starkov Alexey V. Osipov Tatyana V. Andreeva Sergey Yu. Filkin Elena V. Gorbacheva Maxim E. Astashev Victor I. Tsetlin Yuri N. Utkin

Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding. We have recently shown that a protein bitanarin, isolated from the venom of the puff adder Bitis arietans and possessing high phospholipolytic activity, interacts with different types of nicotinic acetylcholine receptors and with the acety...

Journal: :Biotech studies 2023

Snake venom contains various bioactive proteins and peptides, of which enzymes make up a significant portion. Desert Black Cobra (Walterinnesia morgani) is venomous snake distributed mainly in the Middle East including southeastern Türkiye. The aim present study to investigate key enzyme activities protein profile W. morgani originating from Sanliurfa province. After determination content, samp...

Abstract Cancer is the leading cause of death worldwide. Current anticancer drugs involve various toxic side effects; efforts are ongoing to develop new anticancer agents especially from the screening of natural compounds. Present study investigated cytotoxic effects and mode of cell death induced by the Caspian cobra venom in some human cancer cell lines. Cytotoxic effects of snake venom toxin...

Abstract Cancer is the leading cause of death worldwide. Current anticancer drugs involve various toxic side effects; efforts are ongoing to develop new anticancer agents especially from the screening of natural compounds. Present study investigated cytotoxic effects and mode of cell death induced by the Caspian cobra venom in some human cancer cell lines. Cytotoxic effects of snake venom toxin...

2014
Ashis K. Mukherjee Bhargab Kalita Rupamoni Thakur

BACKGROUND The monocled cobra (Naja kaouthia) is responsible for snakebite fatality in Indian subcontinent and in south-western China. Phospholipase A2 (PLA2; EC 3.1.1.4) is one of the toxic components of snake venom. The present study explores the mechanism and rationale(s) for the differences in anticoagulant potency of two acidic PLA2 isoenzymes, Nk-PLA2α (13463.91 Da) and Nk-PLA2β (13282.38...

2017
Bing Chen Wei Fan Jun Zou Siwen Zhang Jin He Chang Shu Guoqing Zhao Tianmeng Sun Zheng Hu Yong-Guang Yang

We have previously shown that human red blood cells (hRBCs) are subject to robust rejection by macrophages in immunodeficient mice. In this study, we found that mouse serum induces hRBC adherence to murine phagocytic cells, including professional phagocytic macrophages and neutrophils and non-professional phagocytic endothelial cells. Complement was found to be responsible for mouse-serum-induc...

Journal: :The Journal of clinical investigation 2000
R F Guo M Huber-Lang X Wang V Sarma V A Padgaonkar R A Craig N C Riedemann S D McClintock T Hlaing M M Shi P A Ward

Multiorgan apoptosis occurs during sepsis. Following cecal ligation and puncture (CLP) in rats, thymocytes underwent apoptosis in a time-dependent manner. C5a blockade dramatically reduced thymocyte apoptosis as measured by thymic weight, binding of annexin V to thymocytes, and laddering of thymocyte DNA. When C5a was generated in vivo by infusion of purified cobra venom factor (CVF), thymocyte...

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