According to a new international classification of vascular lesions, venous vascular malformation has become the most common type of congenital vascular malformation. A characteristic of this disease is its life‐long progressive development, which is the main cause of harm to health and is different from hemangioma. Severe hemangioma with thrombocytopenia (Kasabach–Merritt syndrome)[1] is often...

Abstract Background Snake bite envenoming is a neglected tropical disease with variable clinical presentation, neurotoxic manifestations (respiratory paralysis), rhabdomyolysis, cardiotoxicity, autonomic hyperactivity, and/or coagulation abnormalities. There limited data on the course of envenomation in an incidentally diagnosed COVID-19 patient. Case presentation A 17-year-old male history sna...

Abnormal postpartum hemorrhage is a common problem, complicating 3-5% of vaginal and operative deliveries. In majority cases (98%) uterine atony, retained placenta or genital tract lacerations are responsible for excessive blood loss. However, occasionally, serious coagulopathy may occur early after delivery in specific circumstances such as with placental abruption. Also, when bleeding caused ...

INTRODUCTION After major liver surgery, there are risks of both postoperative bleeding and thrombosis. Routine coagulation monitoring is indicated, but may not provide adequate clinical guidance. Thus, we described the clotting status in a pilot study using broader coagulation testing. We analysed the temporal pattern of coagulation tests to assess whether thromboelastometry (ROTEM®) would impr...

Thrombosis is one of the major complicafiltration on 4% agarose. Fibrin degradations of polycythemia vera. Seventeen pation products were normal and antitients with polycythemia vera in good thrombin III levels were slightly elevated, hematologic control were evaluated for It appears that patients with polycythemia abnormalities of the coagulation system. vera have chronic activation of the coa...

The hemostatic balance is a complex system where the delicate equilibrium is regulated by several factors, including hormones. This review summarizes current knowledge of the effects of most frequent endocrine and metabolic diseases (such as hypothyroidism, hyperthyroidism, Cushing's syndrome, GH-related pituitary dysfunctions, pituitary prolactin-producing adenomas, polycystic ovary syndrome, ...

Coagulopathy in critically ill patients is common and of multifactorial origin [1]. Coagulopathy-associated risk of bleeding and the use of allogeneic blood pro ducts are independent risk factors for morbidity and mortality [2,3]. Th erefore, prompt and correct identifi cation of the underlying causes of these coagulation abnormalities is required, since each coagulation abnormality necessitate...

Single nucleotide polymorphisms (SNPs) of factor V Leiden have been associated with osteonecrosis of the femoral head (ONFH) in Caucasians but remains controversial in Asians. We used an SNP microarray to screen 55 loci of factor V gene in patients with ONFH of Chinese. Significantly different candidate SNPs at 14 loci were analyzed in 146 patients and 116 healthy controls using MALDI-TOF (matr...

Tissue factor pathway inhibitor (TFPI) is an important physiologic inhibitor of the extrinsic pathway of the coagulation system. We investigated whether recombinant TFPI (rTFPI) could reduce pulmonary vascular injury by inhibiting leukocyte activation in rats given lipopolysaccharide (LPS). Pre- or posttreatment of animals with rTFPI significantly inhibited LPS-induced pulmonary vascular injury...

The impairment of formation and maintenance of a formed fibrin clot contributes to the prolonged bleeding and high incidence of rebleeding in upper gastrointestinal haemorrhage. To investigate the basis for the use of drug therapy in gastric bleeding, this study used thrombelastography to determine the effects of pharmacological manipulation of gastric juice on coagulation and fibrinolysis. The...