Many biological polyelectrolytes are capable of undergoing a fluid-fluid phase separation known as complex coacervation. Coacervates were prepared using hyaluronic acid (HA) and a recombinant fusion protein consisting of mussel adhesive motifs and the RGD peptide (fp-151-RGD). The low interfacial energy of the coacervate was exploited to coat titanium (Ti), a metal widely used in implant materi...

Formulation composition has a dramatic influence on coacervate formation in conditioning shampoo. The purpose of this study is to correlate the amount of coacervate formation of novel cationic cassia polymers to the corresponding conditioning profiles on European brown hair using silicone deposition, cationic polymer deposition and sensory evaluation. A design of experiments was conducted by va...

Warfarin, zinc phosphide, norbormide and alphachloralose have been microencapsulated by the technique of coacervation and fed to laboratory rats (R. norvegicus) and mice (M. musculus). Results are given of experiments in which the concentration of rodenticide, wall material and phase ratio have been varied separately and in combination. Experiments are also reported in which normal and encapsul...

For the first time, calorimetric studies performed at very low temperature highlighted the preliminary and required conditions for further aggregation/coacervation of peptides from elastin in solution through the structural water reorganization around the peptides. For this purpose, we firstly characterized by turbidimetry and differential scanning calorimetry the synthetic S4 fragment peptide ...

AIM To develop an innovative delivery system for temozolomide (TMZ) in solid lipid nanoparticles (SLN), which has been preliminarily investigated for the treatment of melanoma. MATERIALS AND METHODS SLN-TMZ was obtained through fatty acid coacervation. Its pharmacological effects were assessed and compared with free TMZ in in vitro and in vivo models of melanoma and glioblastoma. RESULTS Co...

Primate arterial smooth muscle cells and skin fibroblasts were examined for their ability to synthesize elastin in culture. In the presence of the lathyrogen beta-aminopropionitrile, the smooth muscle cells incorporate [3H]lysine into a lysyl oxidase substrate that was present in the medium and associated with the cell layer. A component having a mol wt of 72,000 and an electrophoretic mobility...

This study was aimed at evaluating the flow behavior characteristics of yogurt enriched with fish oil (FO) microcapsules prepared by complex coacervation method. FO was microencapsulated in gelatin-acacia gum coacervates. Then, the microcapsules were dried, and yogurt was produced from the milk enriched with microcapsules powder. Rheological characteristics (as measured using a rotational visco...

The gastrointestinal track has different pH values at sections. Thus, it is not easy to carry a drug the colon for absorption. sensitive polymeric macrosphere carriers have important advantages such as being able be taken orally, targeting active ingredient desired area and dosing concentration long time in target area. In this contex sodium alginate-gelatin macrospheres were produced by disper...

In this study, eight hydrophobic supramolecular (SUPRA) solvents composed of tetrabutylammonium chloride and tetradecyltrimethylammonium bromide as amphiphiles four perfluorinated compounds (hexafluoroisopropanol, trifluoroacetic acid, pentafluoropropionic acid heptafluorobutyric acid) coacervation-inducing agents were developed. The SUPRA phase volumes determined a function individual concentr...