نتایج جستجو برای: cnp

تعداد نتایج: 1053  

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2002
Yoshio Takei Shigehisa Hirose

The natriuretic peptide system of a euryhaline teleost, the Japanese eel (Anguilla japonica), consists of three types of hormones [atrial natriuretic peptide (ANP), ventricular natriuretic peptide (VNP), and C-type natriuretic peptide (CNP)] and four types of receptors [natriuretic peptide receptors (NPR)-A, -B, -C, and -D]. Although ANP is recognized as a volume-regulating hormone that extrude...

Journal: :American journal of physiology. Heart and circulatory physiology 2004
Robert A Rose Alan E Lomax Colleen S Kondo Madhu B Anand-Srivastava Wayne R Giles

The effects of C-type natriuretic peptide (CNP) on heart rate and ionic currents were demonstrated by recording the ECG from adult mice and performing voltage-clamp experiments on single sinoatrial (SA) node cells isolated from mouse heart. The selective natriuretic peptide type C receptor (NPR-C) agonist cANF (10(-7) M) significantly decreased heart rate in the presence of isoproterenol (5 x 1...

Journal: :Hypertension 1997
J Yamashita H Itoh Y Ogawa N Tamura K Takaya T Igaki K Doi T H Chun M Inoue K Masatsugu K Nakao

Growth arrest-specific homeobox (Gax) gene was isolated from rat aorta cDNA library and its expression was largely confined to the cardiovascular tissues. Gax gene was rapidly downregulated by platelet-derived growth factor in vascular smooth muscle cells (VSMCs) and overexpressed Gax was reported to reduce the neointimal thickening after balloon injury in vivo. We have demonstrated that angiot...

Journal: :European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2004
Thomas Schachner Yping Zou Alexander Oberhuber Thomas Mairinger Alexandar Tzankov Günther Laufer Harald Ott Johannes Bonatti

OBJECTIVE C-type natriuretic peptide (CNP), which is produced by vascular endothelial cells, exhibits anti-proliferative and anti-inflammatory effects. Cytotoxic T-lymphocytes may be involved in vein graft disease. Attenuation of vein graft disease necessitates a remodelling of the arterialized vein towards a more contractile phenotype which is characterized, among other factors, by the calponi...

Journal: :The Journal of pharmacology and experimental therapeutics 2016
Tiankai Li Heng-Jie Cheng Nobuyuki Ohte Hiroshi Hasegawa Atsushi Morimoto David M Herrington William C Little Weimin Li Che Ping Cheng

In heart failure (HF), the impaired left ventricular (LV) arterial coupling and diastolic dysfunction present at rest are exacerbated during exercise. C-type natriuretic peptide (CNP) is elevated in HF; however, its functional effects are unclear. We tested the hypotheses that CNP with vasodilating, natriuretic, and positive inotropic and lusitropic actions may prevent this abnormal exercise re...

Journal: :Peptides 2011
Donald F Sellitti Nancy Koles Maria C Mendonça

C-type natriuretic peptide (CNP) is a member of the small family of natriuretic peptides that also includes atrial natriuretic peptide (ANP) and brain, or B-type natriuretic peptide (BNP). Unlike them, it performs its major functions in an autocrine or paracrine manner. Those functions, mediated through binding to the membrane guanylyl cyclase natriuretic peptide receptor B (NPR-B), or by signa...

Journal: :Journal of neurophysiology 2005
Robert A Rose Madhu B Anand-Srivastava Wayne R Giles Jaideep S Bains

Magnocellular neurosecretory cells (MNCs), of the paraventricular and supraoptic nuclei of the hypothalamus, secrete the hormones vasopressin and oxytocin. As a result, they have an essential role in fundamental physiological responses including regulation of blood volume and fluid homeostasis. C-type natriuretic peptide (CNP) is present at high levels in the hypothalamus. Although CNP is known...

2011
Rayomand S Khambata Catherine M Panayiotou Adrian J Hobbs

BACKGROUND AND PURPOSE C-type natriuretic peptide (CNP) is an endothelium-derived vasorelaxant, exerting anti-atherogenic actions in the vasculature and salvaging the myocardium from ischaemic injury. The cytoprotective effects of CNP are mediated in part via the G(i) -coupled natriuretic peptide receptor (NPR)3. As GPCRs are well-known to control cell proliferation, we investigated if NPR3 act...

2013
Dong-Hyeon Lee Ho-Joong Youn Yun-Seok Choi Jong-Min Lee Chul-Soo Park Hae-Ok Jung Hui-Kyung Jeon Man-Young Lee

BACKGROUND AND OBJECTIVES The purpose of this study was to assess the value of C-type natriuretic peptide (CNP) as a surrogate marker for detection of coronary artery spasm in variant angina pectoris (VAP). SUBJECTS AND METHODS Sixty-six patients (mean age: 51±11 years, M : F=40 : 26) who underwent coronary angiography on suspicion of angina and who were diagnosed with VAP by the acetylcholin...

2009
Jeson Sangaralingham Fernando L Martin Paul M McKie Tomoko Ichiki Selma F Mohammed Gerald E Harders Elise A Oehler Horng H Chen Margaret M Redfield John C Burnett

Background Cardiac aging is associated with altered myocardial structure and function that may contribute to the development of heart failure (HF), particularly in the elderly. C-type natriuretic peptide (CNP) is of endothelial cell origin and represents the most potent anti-fibrotic peptide of the natriuretic peptide (NP) family. CNP activates the NP receptor-B (NPR-B), which is found in high ...

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