نتایج جستجو برای: cmax

تعداد نتایج: 3755  

2016
Shinichiro Shirae Yutaka Osawa Kazuhisa Tsuruta

Background: Non-clinical and clinical studies showed efficacy of thrombomodulin alfa for disseminated intravascular coagulation, and its potential efficacy for severe sepsis and coagulopathy. Thrombomodulin alfa is excreted primarily via the kidney and renal function is known to affect the clearance. However the dosing adjustments for patients with renal dysfunction were not warranted, except f...

Journal: :Cancer research 1991
R Patel E M Newman D G Villacorte J K Sato G H Reaman J Z Finklestein M D Krailo G D Hammond J S Holcenberg

Because of the synergy seen in adult trials when 5-fluorouracil is combined with leucovorin, we initiated a Phase I trial of this combination in children's refractory cancer. Leucovorin, an equal mixture of the (6R,S)-diastereoisomers, was administered p.o. for 6 consecutive days as 4 equal doses at 0, 1, 2, and 3 h totaling 500 mg/m2/day. 5-Fluorouracil was given daily on days 2 to 6 as an i.v...

2016
Hsuan-Ming Yao Ann Hsu Suneel Gupta Nishit B. Modi

OBJECTIVES IPX066 is an oral, extended-release capsule formulation of carbidopa-levodopa (CD-LD) available in 4 strengths. The goals of this investigation were to assess the dose proportionality of IPX066 and to study the effects of a high-fat, high-calorie meal and of sprinkling the capsule contents on applesauce on the pharmacokinetics of IPX066 in healthy volunteers. METHODS Three open-lab...

Journal: :British journal of clinical pharmacology 2016
Winnie Sohn Edward Lee Martin K Kankam Ogo Egbuna Graeme Moffat Jeanine Bussiere Desmond Padhi Eric Ng Sandeep Kumar J Greg Slatter

AIMS Denosumab is a fully human monoclonal immunoglobulin G2 antibody that inhibits bone resorption and increases bone mass and strength. The present clinical study assessed serum and seminal fluid pharmacokinetics following a single denosumab dose in healthy men, and evaluated whether denosumab in seminal fluid poses any risk to a fetus in the event of unprotected sexual intercourse with a pre...

Journal: :Thyroid : official journal of the American Thyroid Association 2013
Margarita Gkotsina Marina Michalaki Irene Mamali Georgios Markantes George C Sakellaropoulos Fotios Kalfarentzos Apostolos G Vagenakis Kostas B Markou

BACKGROUND The absorption of levothyroxine (LT4) is affected by many factors. Bariatric surgery is recommended in severely obese patients. The aim of this study was to determine the consequences of bariatric surgery on LT4 pharmacokinetic parameters, and to identify the regions of the gastrointestinal tract where LT4 is absorbed in patients with severe obesity before and after surgery. METHOD...

Journal: :Toxicology letters 2006
A Anadón M Martínez M A Martínez M J Díaz M R Martínez-Larrañaga

The toxicokinetics of lambda-cyhalothrin after single 20 mg kg(-1) oral and 3 mg kg(-1) intravenous doses were studied in rats. Serial blood samples were obtained after oral and intravenous administration. Liver, brain, spinal cord, sciatic nerve, vas deferens, anococcygeus and myenteric plexus tissue samples were also collected. Plasma, liver, hypothalamus, cerebellum, medulla oblongata, front...

Journal: :Antimicrobial agents and chemotherapy 2006
S M Graham D J Bell S Nyirongo R Hartkoorn S A Ward E M Molyneux

Recent pharmacokinetic studies that included children found that serum drug levels were low compared to those of adults for whom the same dosages were used. This study aimed to characterize the pharmacokinetics of pyrazinamide and ethambutol in Malawian children and to examine the impact of age, nutritional status, and human immunodeficiency virus (HIV) infection. We conducted a pharmacokinetic...

Journal: :Nutricion hospitalaria 2013
D A de Luis O Izaola B de la Fuente K Araújo

OBJECTIVES The aim of this study is to compare the glycaemic and insulinemic response of type 2 diabetic patients after oral administration of 250 ml of two enteral formulas: a specific formula (Novasource Diabet Smartflex) against a standard isocaloric formula. METHODS The design was a cross-over study, with the diabetic patients (n = 15) receiving one of the two formulas in random order. Gl...

2018
Ousama Rachid Mutasem Rawas-Qalaji Keith J Simons

Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose of epinephrine is injected from an auto-injector (EAI). Needle phobia highly contributes to EAI underuse, leading to fatalities-especially in children. A novel rapidly-disintegrating sublingual tablet (RDST) of epinephrine was developed in our laboratory as a potential alternative dosage form. The aim...

Journal: :The international journal of neuropsychopharmacology 2014
A Gottås F Boix E L Øiestad V Vindenes J Mørland

After injection, heroin is rapidly metabolized to 6-monoacetylmorphine (6-MAM) and further to morphine. As morphine has been shown to increase striatal dopamine, whereas 6-MAM has not been studied in this respect, we gave i.v. injections of 3 μmol 6-MAM, morphine or heroin to rats. Opioids were measured in blood, and dopamine and opioids in microdialysate from brain striatal extracellular fluid...

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