This work develops a generalized linear skull fracture criterion, the skull fracture correlate, SFC, applicable to impacts by flat targets on the skull in any angle. The SFC is the averaged acceleration over the HIC15 time interval based on data obtained from Hybrid-III headform impact tests. For 15% or less probability of skull fracture the threshold is SFC < 124 g, with a 95% confidence band ...

Growing skull fracture is a rare complication of head injury in which 90% of the cases occur among children less than 3 years old. Only two cases have been reported in the adult population [1, 2]. We report a rounded lytic skull defect in a 75-year-old man that was surgically and pathologically determined to be a growing skull fracture despite a deceptive radiologic appearance simulating a lyti...

Hypophosphatasia is a rare hereditary disorder of bone metabolism.In this article, we presented the case of a male infant with a soft skull and short, deformed limbs at birth, followed by seizures and respiratory distress during admission in the neonatal intensive care unit (NICU). Prenatal ultrasound showed limb hypoplasia, skull hypomineralization, and polyhydramnios. Seizures occurred on day...

The substrate shape specificity of the Escherichia coli ribonuclease P (RNase P) ribozyme depends on the concentration of magnesium ion. At 10 mM or more, it can cleave a hairpin substrate as well as a cloverleaf pre-transfer RNA (tRNA). The results showed, however, that the holo enzyme cleaved the hairpin substrate at low concentrations of magnesium ion. Considering that the homologous E. coli...

The secondary and tertiary structures of the 35S RNA of Rous Sarcoma virus have been investigated. T1 RNase partial digests have been first resolved into their components by gel electrophoresis under non denaturing conditions and then each component analyzed further by various techniques. More than one hundred structured fragments have thus been isolated and shown to consist of several individu...

In a paper published in PNAS, Li et al. (1) solve the long-awaited crystal structure of kindlin-2, which plays a central role in integrin activation, clustering, and signaling (2, 3). Integrins are a large family of heterodimeric adhesion molecules composed of αand β-subunits and expressed on almost all cells. They mediate cell matrix adhesion by binding extracellular matrix proteins, such as c...

Abstract The use of tape conductor poses design challenges for superconducting magnets. Due to its very high aspect ratio, it is hardly possible bend the over thin edges (hard-way bending) rather than wide side (easy-way bending). Overstraining causes critical current degradation. In this paper, we propose a new approach three-dimensional coil layouts and end geometries with conductor, which co...

Craniosynostosis is a serious and common pediatric disease caused by the premature fusion of the sutures of the skull. Early fusion results in severe deformities in skull shape due to the restriction of bone growth perpendicular to the fused suture and compensatory growth in unfused skull plates. Calvarial (skull) abnormalities are frequently associated with severe impaired central nervous syst...

To demonstrate the phylogenetic changes that have led to the current form of the human skull, dried skulls of various representative vertebrates were examined using plain radiography and high-resolution computed tomography. The latter was chosen rather than pluridirectional tomography in anticipation of its future role as the major method for imaging the skull base. The phylogenetic history of ...