PURPOSE To evaluate whether inhibition of the proinflammatory cytokines IL-1β or IL-17A by canakinumab or secukinumab, respectively, influence the signs and symptoms of dry eye. METHODS In a randomized, double-masked, placebo-controlled, outpatient clinical trial, 72 patients with moderate to severe dry eye were randomly assigned in a 1:1:1 ratio to treatment with a single intravenous dose of...

Background: Mitomycin C (MMC) is used to prevent corneal opacity after photorefractive keratectomy (PRK). This study sought determine the effect of MMC on tear film function PRK in eyes with mild-to-moderate myopia.Methods: prospective, contralateral eye comparison was conducted 30 15 patients low-to-moderate myopia referred Alzahra Eye Hospital, Zahedan, Iran. The control group underwent a bal...

BACKGROUND Dry eye disease (DED), a chronic disorder affecting the tear film and lacrimal functional unit, is a widely prevalent condition associated with significant burden and unmet treatment needs. Since specific neural circuits play an important role in maintaining ocular surface health, microelectrical stimulation of these pathways could present a promising new approach to treating DED. Th...

Infrared thermometry was employed by Alio and Padron (1) to study the temperature of the anterior segment of the eye in normal individuals between 15 and 80 years of age, who noted a decrease with advancing age. Efron et al (2) used a wide field color coded infrared imaging device and noted that following a blink, the geometric center of cornea showed cooling at a rate of 0.03±0.02 °C per secon...

PURPOSE To assess the tear film and meibomian gland (MG) features in a Norwegian cohort of patients with primary Sjögren´s syndrome (pSS) and in age- and gender-matched control subjects. METHODS Thirty-four female patients with pSS (age 52.9±11.9 years) and 32 female control subjects (age 49.0±11.5 years) were recruited. After completion of Ocular Surface Disease Index (OSDI) questionnaire an...

BACKGROUND To investigate to what extent Alzheimer's Disease (AD) affects Resting State activity, the possible impairment of independent electrophysiological parameters was determined in Eye-open and Eye-closed Conditions. Specifically, Flash-Visual Evoked Potential (F-VEP) and quantitative EEG (q-EEG) were examined to establish whether abnormalities of the former were systematically associated...

AIM: To evaluate the efficacy and tolerability of administering a combined therapy in patients with dry eye syndrome (DES) associated laryngopharyngeal reflux (LPR). METHODS: The study was retrospective, open, observational, conducted real-life setting. Patients had pathological symptom assessment (SANDE) index (RSI) at baseline. were re-assessed after 1mo end treatment. treatment consisted thr...

OBJECTIVE To determine the frequency of sicca complex, Sjogren's Syndrome (SS) and Fibromyalgia (FM) in patients with Irritable Bowel Syndrome (IBS). METHODS Seventy seven IBS patients who fulfilled the Rome-III criteria were included in the study. All patients were assessed for FM according to the American College of Rheumatology (ACR) 2010 criteria. After examination for objective evidence ...

OBJECTIVES To evaluate ocular surface health in obstructive sleep apnea syndrome (OSAS) and to investigate the tendency of these patients toward dry eyes. MATERIALS AND METHODS Fifty patients who underwent polysomnography and were diagnosed with OSAS and 50 normal control subjects were compared with respect to ocular surface disease index (OSDI), Schirmer I test and tear film break-up time (T...

Dry eye disease (DED) is a multifactorial that represents one of the most common ophthalmologic conditions encountered in everyday clinical practice. Traditional diagnostic tests for DED, such as subjective questionnaires, tear film break-up time and Schirmer test, are often associated with poor reproducibility reliability, which make diagnosis, follow-up, management challenging. New advances i...