Understanding the spatio-temporal variations in frost-free period (FFP) and number of frost days (FD) is beneficial to reduce harmful effects climate change on agricultural production enhancing adaptation. However, FFP FD their response remain unclear across China. To investigate impact FD, trends China from 1950 2020 were quantified using ERA5-Land, a reanalysis dataset with high spatial tempo...

We have systematically investigated the phase diagram of clay particles in water to understand the relation between the local and macroscopic properties and the structures of clay suspensions. We focused, in particular, on sodium Cloisite (CNa) particles at concentrations typically used in nanocomposites (concentrations from 1 to 4 wt %) and at an extended range of ionic strengths (10(-5) to 10...

PURPOSE The purpose of this investigation was to determine the injury profile of the steerable, SF-10A, static-line parachute. METHODS The investigation evaluated prospectively 972 low-level static-line training jumps for major injuries that required CASEVAC from the drop zone and for minor injuries that allowed the jumpers to continue with their training mission. RESULTS The investigation ...

Benzimidazole derivatives are known to represent a class of medicinally important compounds which are extensively used in drug design and catalysis. A series of 2-substituted benzimidazole derivatives 10a-i was herein synthesized from the reaction of o-phenylenediamine with some amino acids using ameliorable pathway. The chemical structures of the synthesized compounds were confirmed by IR, UV,...

BACKGROUND Here, we analyzed the dose- (0.2, 2, 20, 200 nM or 2 μM) and time- (48, 96, 144 and 196 h) dependent activity of a single or repeated exposure of methyl-, butyl- and propylparaben on the proliferation of MCF-7 human breast cancer cells and MCF-10A human breast epithelial cells. Additionally, the effect on estradiol secretion, gene and protein expression of aromatase (CYP19A1) was inv...

In our experimental studies of DNA hybridization as a function of fishing (exposure) time and the subsequent dissociation of bound oligomers, we compared the behaviors of two syntheses of the 59 mer target (labeled 59A and 59B) and 10 mer ODN (labeled 10A and 10B) in different experiments. The two syntheses yield significantly different results. For instance, the fraction of detectable hybridiz...

BACKGROUND Breast cancer development involves a series of mutations in a heterogeneous group of proto-oncogenes/tumor suppressor genes that alter mammary cells to create a microenvironment permissive to tumorigenesis. Exposure to hormones during infertility treatment may have a mutagenic effect on normal mammary epithelial cells, high-risk breast lesions and early-stage breast cancers. Our goal...

BACKGROUND The Malaysian Tualang honey (TH) is not only cytotoxic to human breast cancer cell lines but it has recently been reported to promote the anticancer activity induced by tamoxifen in MCF-7 and MDA-MB-231 cells suggesting its potential as an adjuvant for the chemotherapeutic agent. However, tamoxifen produces adverse effects that could be due to its ability to induce cellular DNA damag...