A boy who had previously had a cleft lip and palate repaired and bilateral orchiopexies presented at 16 years of age with delayed puberty. Isolated gonadotrophin deficiency and testicular hyporesponsiveness to human chorionic gonadotrophin were found. The possibility of bilateral cryptorchidism due to gonadotrophin deficiency should be considered in boys with either cleft lip or palate, or both.

The second and final article of this series describes the embryological classifications of cleft lip and palate patients, their usage and deficiencies. Correspondence: Dr. Syed Nasir Shah Head Department of Prosthodontics Sardar Begum Dental College and Hospital, Gandhara University, Academy Town, Peshawar, Pakistan E-mail: [email protected] JKCD June 2012, Vol. 2, No. 2 87 A review of class...

PURPOSE The aim of this study was to compare the mandibular hard and soft tissue measurements of unilateral and bilateral cleft lip and palate patients with non-cleft individuals. MATERIALS AND METHODS The study sample comprised of lateral cephalograms of 45 subjects. Sample included 15 non-cleft (NC), 15 unilateral cleft lip and palate (UCLP) and 15 bilateral cleft lip and palate (BCLP) case...

OBJECTIVE Mutations in exon 1 of ARHGAP29, a RhoA specific GTPase have been identified in North American and Filipino subjects with nonsyndromic cleft palate and cleft lip with or without cleft palate. Since the genetic status of ARHGAP29 in Indian subjects with nonsyndromic oral clefts is not known, we designed the present study to investigate the occurrence of the above mutations in them. M...

BACKGROUND The goals of this study were to delineate the protocols employed for managing patients with cleft lip and palate deformities, delineate the challenges facing practitioners and patients, and to determine the patient and physician barriers to cleft care delivery in the region. METHODS Survey questionnaires were administered to practitioners attending the second Pan-African Congress o...

non-syndromic cleft lip with or without cleft palate (nscl/p) is one of the most common congenital abnormalities of the orofacial region with a multifactorial etiology. the present study aimed to investigate the association of two common polymorphisms of methylenetetrahydrofolate reductase (mthfr) gene (c.677c>t and c.1298a>c) with the occurrence of nscl/p in an iranian population.forty-five ns...

Introduction: Treatment ofcleft lip and palate patients requires a multidisciplinary plan. These patients usually have a hypoplastic maxilla due to the prior surgical scars. Orthognathic surgery to advance the maxilla in these patients is not very efficient; therefore, orthopedic interventions during an appropriate age seems to be essential.   Case Report: In this article, two cleft lip and pa...

Facial cleft is the second most common congenital deformity. Problems of cleft can be related to esthetic, phonetics, functional insufficiency, emotional, psychological and social. Significant abnormality in nasal cartilage morphology and asymmetry of alar base and columella are associated with cleft lip and alveolar deformity. Pre Nasoalveolar molding (PNAM) is a nonsurgical method of reshapin...

Orofacial clefts, including cleft lip with or without cleft palate, are among the most common visible birth defects, occurring in 1 of every 500 – 1000 live births worldwide ( Murray, 1995 ). With a prevalence of 14.7 per 10 000 births in Australia ( Lancaster and Pedisich, 1995 ), orofacial clefts are the most frequent congenital craniofacial deformities ( Sinko et al. , 2005 ). Cleft lip and...