RATIONALE Patients with chronic kidney disease (CKD) develop hyperhomocysteinemia and have a higher cardiovascular mortality than those without hyperhomocysteinemia by 10-fold. OBJECTIVE We investigated monocyte differentiation in human CKD and cardiovascular disease (CVD). METHODS AND RESULTS We identified CD40 as a CKD-related monocyte activation gene using CKD-monocyte -mRNA array analys...

BACKGROUND AND OBJECTIVES The effectiveness of targeted screening for identification of CKD is largely unknown. The See Kidney Disease (SeeKD) targeted screening project aimed to determine the prevalence of unrecognized CKD in Canada. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS The SeeKD project was conducted across Canada using a convenience sample approach and events to identify adults wi...

OBJECTIVE To examine the relationship between the HW phenotype and risk for CKD in a community population aged 40 years and older. METHODS A cross-sectional study was conducted in Zhuhai from June to October 2012. The participants were divided into three groups: Group 1, Waist circumference >90 cm in men or >85 cm in women and triglycerides ≥2 mmol/l; Group 3, Waist circumference ≤90 cm in me...

BACKGROUND The prevalence in the United States of dietary supplement use that may be harmful to those with chronic kidney disease (CKD) is unknown. We sought to characterize potentially harmful supplement use by individual CKD status. STUDY DESIGN Cross-sectional national survey (National Health and Nutrition Examination Survey, 1999-2008). SETTING & PARTICIPANTS Community-based survey of 2...

Background: Vascular disease is unfortunately an asymptomatic process that is responsible for a variety of organ damages such as chronic kidney disease (CKD). Present therapeutic strategy in CKD which is usually initiated at the late stage of CKD fails to enhance renal perfusion or restore function. Objective: To summarize the mechanism of vascular homeostasis in different stages of CKD to expl...

INTRODUCTION Most UK laboratories use the MDRD4 formula to estimate glomerular filtration rate (eGFR), but this may exaggerate chronic kidney disease (CKD) prevalence. In a large adult population, we examined the impact of the more accurate CKD-EPI formulae on prevalence estimates, and on secular trends in prevalence. METHODS We extracted all serum creatinine (SCr) results for adults, process...

BACKGROUND Chronic kidney disease (CKD) is a condition associated with progressive loss of kidney function and kidney damage. The two common causes of CKD are diabetes mellitus and hypertension. Other causes of CKD also include polycystic kidney disease, obstructive uropathy and primary glomerulonephritis. The receptor for advanced glycation end-products (RAGE) is a multi-ligand cell surface re...

The aim of this study is to investigate the impact of serum Mg on bone mineral metabolism in chronic kidney disease (CKD) patients with or without diabetes. A total of 56 CKD patients not receiving dialysis were recruited and divided into two groups, one group of 27 CKD patients with diabetes and another group of 29 CKD patients without diabetes. Biochemical determinations were made, and the es...

BACKGROUND/AIMS Anthropometric measures such as body mass index (BMI) and waist circumference (WC) have differential associations with incident chronic kidney disease (CKD) and mortality. We examined the associations of BMI and WC with various CKD complications. METHODS We conducted a cross-sectional analysis of 2,853 adult participants with CKD in the National Health and Nutrition Examinatio...