The reaction of tetrapyrazine Pt(II) with adenine under basic conditions yielded two products both disubstituted by adenine and bound in all cases to the N-9 nitrogen of adenine. Crystals amenable to X-crystallographic analysis were obtained for one product which was consequently identified as trans-[Pt(II)(N9-adeH)2(pz)2](NO3)(4).H2O. The other product, though, was identified as the cis isomer...

Modifications in the structure of a 260 bp DNA (hlyM) fragment from Escherichia coli caused by interaction with Pd(II) and Pt(II) complexes were studied. Cisplatin and transplatin [cis- and trans-PtCl2(NH3)2 respectively], Pt2Cl2(Spym)4 (Spym = 2-mercaptopyrimidine anion), Pd-famotidine and Pt-famotidine were incubated with DNA for 24 h at 37 degrees C and then observed with an atomic force mic...

New Pt complexes of chelating bisguanidines and guanidinate ligands were synthesized and characterized. 1,2-Bis(N,N,N',N'-tetramethylguanidino)benzene (btmgb) was used as a neutral chelating bisguanidine ligand, and 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidinate (hpp(-)) as a guanidinate ligand. The salts [btmgbH]+[HOB(C6F5)3](-) and [btmgbH2]Cl2 and the complexes [(btmgb)PtCl2], [(btmgb)...

The title compound, {[PtYb(CN)(4)(NO(3))(C(15)H(11)N(3))(H(2)O)(2)]·CH(3)CN}(n), was isolated from solution as a one-dimensional coordination polymer. The Yb(3+) site has ninefold coordination with a distorted tricapped trigonal-prismatic geometry, while the Pt(II) ion is coordinated by four cyanide groups in an almost regular square-planar geometry. cis-Bridging by the tetra-cyanidoplatinate(I...

the therrmodynamic parameters and equilibrium constant of displacement of dimethy sulfide by 3-carboaldehyde pyridine as n-donor ligand in cis-[pt(4-mec6h4)2(sme2)2] complex have been measured using uv vis spectroscopy in acetone, dichloromethane and benzene at various temperatures (t=15-20 °c) and compared with previous my reported about similar reaction. δho (kj.mol-1) of the mentioned reacti...

The therrmodynamic parameters and equilibrium constant of displacement of dimethy sulfide by 3-carboaldehyde pyridine as N-donor ligand in cis-[Pt(4-MeC6H4)2(SMe2)2] complex have been measured using UV vis spectroscopy in acetone, dichloromethane and benzene at various temperatures (T=15-20 °C) and compared with previous my reported about similar reaction. ΔHo (KJ.mol-1) of the mentioned reacti...

In vitro immune effects of Pt compounds of occupational and/or environmental importance, or those used in cancer treatment were studied. Spontaneous and PHA-stimulated proliferation of peripheral blood mononuclear cells (PBMC) and in vitro release of TNF-alpha, IFN-gamma, and IL-5 were assessed in presence of high and very low concentrations of Pt salts: 10(-4) and 10(-7) M (NH4)2[PtCl6], (NH4)...

The human metallo-chaperone protein Atox1 features a high affinity Cu(I) binding site Cys(12)GlyGlyCys(15) (KD = 10(-17.4) M at pH 7.0) and delivers copper to the trans-Golgi network (TGN). Atox1 may participate in the metabolism of the drug cis-Pt(NH3)2Cl2 (cisplatin), either as a component of its delivery to the nucleus or of its loss via transport to the TGN and beyond. The species of stoich...

Introduction. Male infertility is one of the main causes forced childlessness couples around world. Currently, a limited number drugs for treatment male are available on market. Biologically active supplements (dietary supplements) containing L-carnitine often used in complex therapy. The results determining therapeutic activity new drug, peptide obtained from cattle testes (PP-R-001) and compa...